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10.7554/eLife.61339 http://scihub22266oqcxt.onion/10.7554/eLife.61339 33242000!7843133!33242000     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33242000&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Elife 2020 ; 9 (?): ? Nephropedia Template TP {{tp|p=33242000|t=2020. Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory |pdf=|usr=}}{{33242000}} gab.com Text Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33242000 #FOAvip Dietary magnesium (Mg(2+)) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg(2+) feeding also enhances long-term memory in Drosophila. Normal and Mg(2+)-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg(2+)-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg(2+). We propose that regulated neuronal Mg(2+) efflux is critical for normal and Mg(2+)-enhanced memory. Twit Text FOAVip Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33242000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33242000 #FOAvip English Wikipedia <ref>{{Cite pmid|33242000}}</ref> Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory #MMPMID33242000 Wu Y; Funato Y; Meschi E; Jovanoski KD; Miki H; Waddell S Elife 2020[Nov]; 9 (?): ? PMID33242000show ga Dietary magnesium (Mg(2+)) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate receptor. Here we show that Mg(2+) feeding also enhances long-term memory in Drosophila. Normal and Mg(2+)-enhanced fly memory appears independent of NMDA receptors in the mushroom body and instead requires expression of a conserved CNNM-type Mg(2+)-efflux transporter encoded by the unextended (uex) gene. UEX contains a putative cyclic nucleotide-binding homology domain and its mutation separates a vital role for uex from a function in memory. Moreover, UEX localization in mushroom body Kenyon cells (KCs) is altered in memory-defective flies harboring mutations in cAMP-related genes. Functional imaging suggests that UEX-dependent efflux is required for slow rhythmic maintenance of KC Mg(2+). We propose that regulated neuronal Mg(2+) efflux is critical for normal and Mg(2+)-enhanced memory. |Animals[MESH] |Drosophila Proteins/metabolism[MESH] |Drosophila melanogaster/*metabolism[MESH] |Hippocampus/*physiology[MESH] |Magnesium/*metabolism[MESH] |Memory/*physiology[MESH] |Mushroom Bodies/physiology[MESH] |Neurons/physiology[MESH]Magnesium efflux from Drosophila Kenyon cells is critical for normal a(epmc).pdf DeepDyve Pubget Overpricing