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10.1002/anie.202013848 http://scihub22266oqcxt.onion/10.1002/anie.202013848 33241871!7753697!33241871     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Angew+Chem+Int+Ed+Engl 2021 ; 60 (11): 6101-6106 Nephropedia Template TP {{tp|p=33241871|t=2021. Translation of Mycobacterium Survival Strategy to Develop a Lipo-peptide based Fusion Inhibitor* |pdf=|usr=}}{{33241871}} gab.com Text Translation of Mycobacterium Survival Strategy to Develop a Lipo-peptide based Fusion Inhibitor* JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33241871 #FOAvip The entry of enveloped virus requires the fusion of viral and host cell membranes. An effective fusion inhibitor aiming at impeding such membrane fusion may emerge as a broad-spectrum antiviral agent against a wide range of viral infections. Mycobacterium survives inside the phagosome by inhibiting phagosome-lysosome fusion with the help of a coat protein coronin 1. Structural analysis of coronin 1 and other WD40-repeat protein suggest that the trp-asp (WD) sequence is placed at distorted beta-meander motif (more exposed) in coronin 1. The unique structural feature of coronin 1 was explored to identify a simple lipo-peptide sequence (myr-WD), which effectively inhibits membrane fusion by modulating the interfacial order, water penetration, and surface potential. The mycobacterium inspired lipo-dipeptide was successfully tested to combat type 1 influenza virus (H1N1) and murine coronavirus infections as a potential broad-spectrum antiviral agent. Twit Text FOAVip Translation of Mycobacterium Survival Strategy to Develop a Lipo-peptide based Fusion Inhibitor* ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=33241871 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33241871 #FOAvip English Wikipedia <ref>{{Cite pmid|33241871}}</ref> Translation of Mycobacterium Survival Strategy to Develop a Lipo-peptide based Fusion Inhibitor* #MMPMID33241871 Sardar A; Lahiri A; Kamble M; Mallick AI; Tarafdar PK Angew Chem Int Ed Engl 2021[Mar]; 60 (11): 6101-6106 PMID33241871show ga The entry of enveloped virus requires the fusion of viral and host cell membranes. An effective fusion inhibitor aiming at impeding such membrane fusion may emerge as a broad-spectrum antiviral agent against a wide range of viral infections. Mycobacterium survives inside the phagosome by inhibiting phagosome-lysosome fusion with the help of a coat protein coronin 1. Structural analysis of coronin 1 and other WD40-repeat protein suggest that the trp-asp (WD) sequence is placed at distorted beta-meander motif (more exposed) in coronin 1. The unique structural feature of coronin 1 was explored to identify a simple lipo-peptide sequence (myr-WD), which effectively inhibits membrane fusion by modulating the interfacial order, water penetration, and surface potential. The mycobacterium inspired lipo-dipeptide was successfully tested to combat type 1 influenza virus (H1N1) and murine coronavirus infections as a potential broad-spectrum antiviral agent. |Animals[MESH] |Antiviral Agents/chemistry/*pharmacology/toxicity[MESH] |Dipeptides/chemistry/*pharmacology/toxicity[MESH] |Dogs[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/drug effects[MESH] |Lipopeptides/chemistry/*pharmacology/toxicity[MESH] |Liposomes/chemistry[MESH] |Madin Darby Canine Kidney Cells[MESH] |Membrane Fusion/*drug effects[MESH] |Murine hepatitis virus/drug effects[MESH] |Phosphatidylcholines/chemistry[MESH] |Phosphatidylethanolamines/chemistry[MESH] |Rats[MESH]Translation of Mycobacterium Survival Strategy to Develop a Lipo-pepti(epmc).pdf DeepDyve Pubget Overpricing