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10.7717/peerj.10336 http://scihub22266oqcxt.onion/10.7717/peerj.10336 33240650!7678445!33240650     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33240650&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       PeerJ 2020 ; 8 (?): e10336 Nephropedia Template TP {{tp|p=33240650|t=2020. Analysis of genes and underlying mechanisms involved in foam cells formation and atherosclerosis development |pdf=|usr=}}{{33240650}} gab.com Text Analysis of genes and underlying mechanisms involved in foam cells formation and atherosclerosis development JO: PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=33240650 #FOAvip BACKGROUND: Foam cells (FCs) play crucial roles in the process of all stages of atherosclerosis. Smooth muscle cells (SMCs) and macrophages are the major sources of FCs. This study aimed to identify the common molecular mechanism in these two types of FCs. METHODS: GSE28829, GSE43292, GSE68021, and GSE54666 were included to identify the differentially expressed genes (DEGs) associated with FCs derived from SMCs and macrophages. Gene Ontology biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed by using the DAVID database. The co-regulated genes associated with the two origins of FCs were validated (GSE9874), and their expression in vulnerable atherosclerosis plaques (GSE120521 and GSE41571) was assessed. RESULTS: A total of 432 genes associated with FCs derived from SMCs (SMC-FCs) and 81 genes associated with FCs derived from macrophages (M-FCs) were identified, and they were mainly involved in lipid metabolism, inflammation, cell cycle/apoptosis. Furthermore, three co-regulated genes associated with FCs were identified: GLRX, RNF13, and ABCA1. These three common genes showed an increased tendency in unstable or ruptured plaques, although in some cases, no statistically significant difference was found. CONCLUSIONS: DEGs related to FCs derived from SMCs and macrophages have contributed to the understanding of the molecular mechanism underlying the formation of FCs and atherosclerosis. GLRX, RNF13, and ABCA1 might be potential targets for atherosclerosis treatment. Twit Text FOAVip Analysis of genes and underlying mechanisms involved in foam cells formation and atherosclerosis development ????PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=33240650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33240650 #FOAvip English Wikipedia <ref>{{Cite pmid|33240650}}</ref> Analysis of genes and underlying mechanisms involved in foam cells formation and atherosclerosis development #MMPMID33240650 Zhang K; Qin X; Zhou X; Zhou J; Wen P; Chen S; Wu M; Wu Y; Zhuang J PeerJ 2020[]; 8 (?): e10336 PMID33240650show ga BACKGROUND: Foam cells (FCs) play crucial roles in the process of all stages of atherosclerosis. Smooth muscle cells (SMCs) and macrophages are the major sources of FCs. This study aimed to identify the common molecular mechanism in these two types of FCs. METHODS: GSE28829, GSE43292, GSE68021, and GSE54666 were included to identify the differentially expressed genes (DEGs) associated with FCs derived from SMCs and macrophages. Gene Ontology biological process (GO-BP) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed by using the DAVID database. The co-regulated genes associated with the two origins of FCs were validated (GSE9874), and their expression in vulnerable atherosclerosis plaques (GSE120521 and GSE41571) was assessed. RESULTS: A total of 432 genes associated with FCs derived from SMCs (SMC-FCs) and 81 genes associated with FCs derived from macrophages (M-FCs) were identified, and they were mainly involved in lipid metabolism, inflammation, cell cycle/apoptosis. Furthermore, three co-regulated genes associated with FCs were identified: GLRX, RNF13, and ABCA1. These three common genes showed an increased tendency in unstable or ruptured plaques, although in some cases, no statistically significant difference was found. CONCLUSIONS: DEGs related to FCs derived from SMCs and macrophages have contributed to the understanding of the molecular mechanism underlying the formation of FCs and atherosclerosis. GLRX, RNF13, and ABCA1 might be potential targets for atherosclerosis treatment. ?Analysis of genes and underlying mechanisms involved in foam cells for(epmc).pdf DeepDyve Pubget Overpricing