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10.1038/s41598-020-77525-w http://scihub22266oqcxt.onion/10.1038/s41598-020-77525-w 33239683!7689507!33239683     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 20533 Nephropedia Template TP {{tp|p=33239683|t=2020. Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19 |pdf=|usr=}}{{33239683}} gab.com Text Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33239683 #FOAvip SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12-15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNgamma, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification. Twit Text FOAVip Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33239683 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33239683 #FOAvip English Wikipedia <ref>{{Cite pmid|33239683}}</ref> Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19 #MMPMID33239683 Haljasmagi L; Salumets A; Rumm AP; Jurgenson M; Krassohhina E; Remm A; Sein H; Kareinen L; Vapalahti O; Sironen T; Peterson H; Milani L; Tamm A; Hayday A; Kisand K; Peterson P Sci Rep 2020[Nov]; 10 (1): 20533 PMID33239683show ga SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12-15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNgamma, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification. |*Apoptosis[MESH] |*Proteome[MESH] |*Severity of Illness Index[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |COVID-19 Testing/*methods[MESH] |COVID-19/*blood/*diagnosis/virology[MESH] |Caspase 8/*blood[MESH] |Chemokines/*blood[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Inflammation/blood[MESH] |Intensive Care Units[MESH] |Longitudinal Studies[MESH] |Male[MESH] |Middle Aged[MESH] |Proteomics/methods[MESH] |Risk Factors[MESH] |SARS-CoV-2/*genetics[MESH] |Up-Regulation[MESH]Longitudinal proteomic profiling reveals increased early inflammation (epmc).pdf DeepDyve Pubget Overpricing