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10.1073/pnas.2012197117 http://scihub22266oqcxt.onion/10.1073/pnas.2012197117 33239446!7749331!33239446     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (50): 32105-32113 Nephropedia Template TP {{tp|p=33239446|t=2020. Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion |pdf=|usr=}}{{33239446}} gab.com Text Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=33239446 #FOAvip Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-stimulated gene screen against vesicular stomatitis virus (VSV)-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identified CH25H and its enzymatic product 25-hydroxycholesterol (25HC) as potent inhibitors of SARS-CoV-2 replication. Internalized 25HC accumulates in the late endosomes and potentially restricts SARS-CoV-2 spike protein catalyzed membrane fusion via blockade of cholesterol export. Our results highlight one of the possible antiviral mechanisms of 25HC and provide the molecular basis for its therapeutic development. Twit Text FOAVip Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=33239446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33239446 #FOAvip English Wikipedia <ref>{{Cite pmid|33239446}}</ref> Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion #MMPMID33239446 Zang R; Case JB; Yutuc E; Ma X; Shen S; Gomez Castro MF; Liu Z; Zeng Q; Zhao H; Son J; Rothlauf PW; Kreutzberger AJB; Hou G; Zhang H; Bose S; Wang X; Vahey MD; Mani K; Griffiths WJ; Kirchhausen T; Fremont DH; Guo H; Diwan A; Wang Y; Diamond MS; Whelan SPJ; Ding S Proc Natl Acad Sci U S A 2020[Dec]; 117 (50): 32105-32113 PMID33239446show ga Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-stimulated gene that shows broad antiviral activities against a wide range of enveloped viruses. Here, using an IFN-stimulated gene screen against vesicular stomatitis virus (VSV)-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identified CH25H and its enzymatic product 25-hydroxycholesterol (25HC) as potent inhibitors of SARS-CoV-2 replication. Internalized 25HC accumulates in the late endosomes and potentially restricts SARS-CoV-2 spike protein catalyzed membrane fusion via blockade of cholesterol export. Our results highlight one of the possible antiviral mechanisms of 25HC and provide the molecular basis for its therapeutic development. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19/metabolism/pathology/virology[MESH] |Endosomes/*genetics/metabolism[MESH] |Humans[MESH] |Hydroxycholesterols/*pharmacology[MESH] |Interferons/metabolism[MESH] |Membrane Fusion/drug effects[MESH] |SARS-CoV-2/drug effects/metabolism/pathogenicity[MESH] |Severe acute respiratory syndrome-related coronavirus/drug effects/metabolism/pathogenicity[MESH] |Spike Glycoprotein, Coronavirus/*antagonists & inhibitors/genetics[MESH] |Virus Internalization/drug effects[MESH]Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocki(epmc).pdf DeepDyve Pubget Overpricing