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10.1128/JCM.02727-20

http://scihub22266oqcxt.onion/10.1128/JCM.02727-20
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33239376!8111148!33239376
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suck abstract from ncbi


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pmid33239376      J+Clin+Microbiol 2021 ; 59 (2): ä
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  • Comparison of the Quidel Sofia SARS FIA Test to the Hologic Aptima SARS-CoV-2 TMA Test for Diagnosis of COVID-19 in Symptomatic Outpatients #MMPMID33239376
  • Beck ET; Paar W; Fojut L; Serwe J; Jahnke RR
  • J Clin Microbiol 2021[Jan]; 59 (2): ä PMID33239376show ga
  • The Quidel Sofia severe acute respiratory syndrome (SARS) fluorescent immunoassay (FIA) test (SOFIA) is a rapid antigen immunoassay for the detection of SARS coronavirus 2 (SARS-CoV-2) proteins from nasal or nasopharyngeal swab specimens. The purpose of this study was to compare the results of the SOFIA test to those of the Hologic Aptima SARS-CoV-2 TMA test (APTIMA TMA), a high-throughput molecular diagnostic test that uses transcription-mediated amplification (TMA) for the detection of SARS-CoV-2 nucleic acid from upper respiratory tract specimens. Three hundred forty-seven symptomatic patients from an urgent care center in an area with a high prevalence of SARS-CoV-2 infections were tested in parallel using nasal swabs for the SOFIA test and nasopharyngeal swabs for the APTIMA TMA test. The SOFIA test demonstrated a positive percent agreement (PPA) of 82.0% with the APTIMA TMA test for symptomatic patients tested 5 days from symptom onset. The Cepheid Xpert Xpress SARS-CoV-2 reverse transcription-PCR (RT-PCR) test was used to determine the cycle threshold (C(T) ) value for any specimens that were discrepant between the SOFIA and APTIMA TMA tests. Using a C(T) value of
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Ambulatory Care Facilities[MESH]
  • |Antigens, Viral/analysis[MESH]
  • |COVID-19 Testing/*methods[MESH]
  • |COVID-19/*diagnosis/pathology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Diagnostic Tests, Routine[MESH]
  • |Fluoroimmunoassay[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Middle Aged[MESH]
  • |Molecular Diagnostic Techniques[MESH]
  • |Nasopharynx/virology[MESH]
  • |SARS-CoV-2/genetics/immunology/*isolation & purification[MESH]
  • |Sensitivity and Specificity[MESH]


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