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10.3390/ijms21228873

http://scihub22266oqcxt.onion/10.3390/ijms21228873
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33238622!7700406!33238622
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suck abstract from ncbi

pmid33238622      Int+J+Mol+Sci 2020 ; 21 (22): ?
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  • Combination Therapy to Treat Fungal Biofilm-Based Infections #MMPMID33238622
  • Tits J; Cammue BPA; Thevissen K
  • Int J Mol Sci 2020[Nov]; 21 (22): ? PMID33238622show ga
  • An increasing number of people is affected by fungal biofilm-based infections, which are resistant to the majority of currently-used antifungal drugs. Such infections are often caused by species from the genera Candida, Aspergillus or Cryptococcus. Only a few antifungal drugs, including echinocandins and liposomal formulations of amphotericin B, are available to treat such biofilm-based fungal infections. This review discusses combination therapy as a novel antibiofilm strategy. More specifically, in vitro methods to discover new antibiofilm combinations will be discussed. Furthermore, an overview of the main modes of action of promising antibiofilm combination treatments will be provided as this knowledge may facilitate the optimization of existing antibiofilm combinations or the development of new ones with a similar mode of action.
  • |Antifungal Agents/*therapeutic use[MESH]
  • |Biofilms/*drug effects[MESH]
  • |Candida/drug effects/pathogenicity[MESH]
  • |Drug Resistance, Fungal/*drug effects[MESH]
  • |Humans[MESH]
  • |Microbial Sensitivity Tests[MESH]


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