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10.1002/sctm.20-0189 http://scihub22266oqcxt.onion/10.1002/sctm.20-0189 33237619!7753753!33237619     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33237619&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Stem+Cells+Transl+Med 2021 ; 10 (4): 568-571 Nephropedia Template TP {{tp|p=33237619|t=2021. Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure |pdf=|usr=}}{{33237619}} gab.com Text Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure JO: Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=33237619 #FOAvip The use of mesenchymal stem cells (MSC) derived from several sources has been suggested as a major anti-inflammation strategy during the recent outbreak of coronavirus-19 (COVID-19). As the virus enters the target cells through the receptor ACE2, it is important to determine if the MSC population transfused to patients could also be a target for the virus entry. We report here that ACE2 is highly expressed in adult bone marrow, adipose tissue, or umbilical cord-derived MSC. On the other hand, placenta-derived MSC express low levels of ACE2 but only in early passages of cultures. MSC derived from human embryonic stem cell or human induced pluripotent stem cells express also very low levels of ACE2. The transcriptome analysis of the MSCs with lowest expression of ACE2 in fetal-like MSCs is found to be associated in particularly with an anti-inflammatory signature. These results are of major interest for designing future clinical MSC-based stem cell therapies for severe COVID-19 infections. Twit Text FOAVip Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure ????Stem Cells Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=33237619 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33237619 #FOAvip English Wikipedia <ref>{{Cite pmid|33237619}}</ref> Molecular investigation of adequate sources of mesenchymal stem cells for cell therapy of COVID-19-associated organ failure #MMPMID33237619 Desterke C; Griscelli F; Imeri J; Marcoux P; Lemonnier T; Latsis T; Turhan AG; Bennaceur-Griscelli A Stem Cells Transl Med 2021[Apr]; 10 (4): 568-571 PMID33237619show ga The use of mesenchymal stem cells (MSC) derived from several sources has been suggested as a major anti-inflammation strategy during the recent outbreak of coronavirus-19 (COVID-19). As the virus enters the target cells through the receptor ACE2, it is important to determine if the MSC population transfused to patients could also be a target for the virus entry. We report here that ACE2 is highly expressed in adult bone marrow, adipose tissue, or umbilical cord-derived MSC. On the other hand, placenta-derived MSC express low levels of ACE2 but only in early passages of cultures. MSC derived from human embryonic stem cell or human induced pluripotent stem cells express also very low levels of ACE2. The transcriptome analysis of the MSCs with lowest expression of ACE2 in fetal-like MSCs is found to be associated in particularly with an anti-inflammatory signature. These results are of major interest for designing future clinical MSC-based stem cell therapies for severe COVID-19 infections. |*Cell- and Tissue-Based Therapy[MESH] |*Mesenchymal Stem Cells/immunology/pathology/virology[MESH] |Adult[MESH] |Angiotensin-Converting Enzyme 2/*immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Male[MESH] |Organ Specificity/immunology[MESH] |SARS-CoV-2/*immunology[MESH]Molecular investigation of adequate sources of mesenchymal stem cells (epmc).pdf DeepDyve Pubget Overpricing