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suck abstract from ncbi


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pmid33236584      Isr+Med+Assoc+J 2020 ; 22 (8): 505-513
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  • The Hyper-Inflammatory Response in Adults with Severe COVID-19 Pneumonia Differs from the Cytokine Storm of Hemophagocytic Syndrome #MMPMID33236584
  • Brikman S; Bieber A; Dori G
  • Isr Med Assoc J 2020[Aug]; 22 (8): 505-513 PMID33236584show ga
  • In this review we described the values of commonly available HScore laboratory markers in patients with coronavirus-19 (COVID-19)-pneumonia associated cytokine storm syndrome (CPN-CSS) and compared results with those of other forms cytokine storm syndrome (O-CSS) to determine a pattern for CPN-CSS. Twelve CPN-CSS studies and six O-CSS studies were included. CPN-CSS typically obtained a single HScore value (e.g., aspartate transaminase > 30 U/L) while failing all other HScore criteria. A typical pattern for CPN-CSS was revealed when compared to O-CSS: lymphopenia vs. pancytopenia and increased vs. decreased fibrinogen. Findings, other than HScore commonly found in CPN-CSS studies, showed elevated lactate dehydrogenase, D-dimer, and C-reactive protein. Although CPN-CSS studies describe severely ill patients, the HScore markers are typically less toxic that O-CSS.
  • |Aspartate Aminotransferases/blood[MESH]
  • |C-Reactive Protein/metabolism[MESH]
  • |COVID-19/*blood/*complications[MESH]
  • |Cytokine Release Syndrome/*blood/*etiology[MESH]
  • |Ferritins/blood[MESH]
  • |Fibrin Fibrinogen Degradation Products/metabolism[MESH]
  • |Fibrinogen/metabolism[MESH]
  • |Humans[MESH]
  • |L-Lactate Dehydrogenase/blood[MESH]
  • |Lymphohistiocytosis, Hemophagocytic/blood/complications[MESH]
  • |Lymphopenia/virology[MESH]
  • |Pancytopenia/etiology[MESH]
  • |Patient Acuity[MESH]
  • |Pneumonia/*blood/*virology[MESH]


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