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10.1111/pai.13363

http://scihub22266oqcxt.onion/10.1111/pai.13363
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33236427!7753582!33236427
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suck abstract from ncbi


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pmid33236427      Pediatr+Allergy+Immunol 2020 ; 31 Suppl 26 (Suppl 26): 75-78
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  • Immunological basis of virus-host interaction in COVID-19 #MMPMID33236427
  • La Torre F; Leonardi L; Giardino G; Volpi S; Federici S; Soresina A; Cancrini C; Lougaris V; Castagnoli R; Corrente S; Cardinale F
  • Pediatr Allergy Immunol 2020[Nov]; 31 Suppl 26 (Suppl 26): 75-78 PMID33236427show ga
  • COVID-19 is a complex new viral disease, in which a strict balance between anti-viral immune response and the ensuing organ inflammation has a critical role in determining the clinical course. In adults, compelling evidence exists indicating that an uncontrolled inflammatory response ("cytokine storm") is pivotal in determining disease progression and mortality. Children may rarely present with severe disease. Modulating factors related to the host's genetic factors, age-related susceptibility, and the capability to mount appropriate immune responses might play a role in control virus load at an early stage and regulating the inflammatory reaction. Elucidating these mechanisms seems crucial in developing target therapies according to patient's age, immunologic status, and disease evolution in COVID-19.
  • |*SARS-CoV-2[MESH]
  • |COVID-19/etiology/*immunology[MESH]
  • |Cytokine Release Syndrome[MESH]
  • |Host Microbial Interactions/*immunology[MESH]
  • |Humans[MESH]


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