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10.1111/pai.13358 http://scihub22266oqcxt.onion/10.1111/pai.13358 33236418!7753284!33236418     free     free     free       Pediatr+Allergy+Immunol 2020 ; 31 Suppl 26 (Suppl 26): 63-65 Nephropedia Template TP {{tp|p=33236418|t=2020. HMGB1: A pleiotropic activity |pdf=|usr=}}{{33236418}} gab.com Text HMGB1: A pleiotropic activity JO: Pediatr Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33236418 #FOAvip High-mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage-associated molecular pattern (DAMP) molecules, also called alarmins. For this, HMGB1 has been studied in several acute and chronic inflammatory diseases as an early biomarker of inflammation. An increased concentration of HMGB1 has been detected in serum, as the expression of systemic inflammation, and in specific samples (such as stool, synovial fluid, nasal lavage fluid, sputum, and cerebrospinal fluid), as the expression of local production, in several infectious and/or inflammatory diseases. These data are particularly important because they open new futuristic possibilities for target therapies, potentially also for the COVID-19 treatment. Twit Text FOAVip HMGB1: A pleiotropic activity ????Pediatr Allergy Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33236418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33236418 #FOAvip English Wikipedia <ref>{{Cite pmid|33236418}}</ref> HMGB1: A pleiotropic activity #MMPMID33236418 Colavita L; Ciprandi G; Salpietro A; Cuppari C Pediatr Allergy Immunol 2020[Nov]; 31 Suppl 26 (Suppl 26): 63-65 PMID33236418show ga High-mobility group box 1 (HMGB1) is a nuclear protein involved in DNA replication, transcription, recombination, and repair. In the extracellular space, the HMGB1 plays an essential role in the onset and perpetuation of inflammation, belonging to the group of damage-associated molecular pattern (DAMP) molecules, also called alarmins. For this, HMGB1 has been studied in several acute and chronic inflammatory diseases as an early biomarker of inflammation. An increased concentration of HMGB1 has been detected in serum, as the expression of systemic inflammation, and in specific samples (such as stool, synovial fluid, nasal lavage fluid, sputum, and cerebrospinal fluid), as the expression of local production, in several infectious and/or inflammatory diseases. These data are particularly important because they open new futuristic possibilities for target therapies, potentially also for the COVID-19 treatment. |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |HMGB1 Protein/antagonists & inhibitors/blood/*physiology[MESH]HMGB1: A pleiotropic activity (epmc).pdf DeepDyve Pubget Overpricing