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10.1111/aor.13873

http://scihub22266oqcxt.onion/10.1111/aor.13873
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33236373!7753822!33236373
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suck abstract from ncbi


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pmid33236373      Artif+Organs 2021 ; 45 (6): E158-E170
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  • Role of extracorporeal membrane oxygenation in critically Ill COVID-19 patients and predictors of mortality #MMPMID33236373
  • Zayat R; Kalverkamp S; Grottke O; Durak K; Dreher M; Autschbach R; Marx G; Marx N; Spillner J; Kersten A
  • Artif Organs 2021[Jun]; 45 (6): E158-E170 PMID33236373show ga
  • The role of extracorporeal membrane oxygenation (ECMO) in the management of critically ill COVID-19 patients remains unclear. Our study aims to analyze the outcomes and risk factors from patients treated with ECMO. This retrospective, single-center study includes 17 COVID-19 patients treated with ECMO. Univariate and multivariate parametric survival regression identified predictors of survival. Nine patients (53%) were successfully weaned from ECMO and discharged. The incidence of in-hospital mortality was 47%. In a univariate analysis, only four out of 83 pre-ECMO variables were significantly different; IL-6, PCT, and NT-proBNP were significantly higher in non-survivors than in survivors. The Respiratory Extracorporeal Membrane Oxygenation Survival Prediction (RESP) score was significantly higher in survivors. After a multivariate parametric survival regression, IL-6, NT-proBNP and RESP scores remained significant independent predictors, with hazard ratios (HR) of 1.069 [95%-CI: 0.986-1.160], P = .016 1.001 [95%-CI: 1.000-1.001], P = .012; and .843 [95%-CI: 0.564-1.260], P = .040, respectively. A prediction model comprising IL-6, NT-proBNP, and RESP score showed an area under the curve (AUC) of 0.87, with a sensitivity of 87.5% and 77.8% specificity compared to an AUC of 0.79 for the RESP score alone. The present study suggests that ECMO is a potentially lifesaving treatment for selected critically ill COVID-19 patients. Considering IL-6 and NT-pro-BNP, in addition to the RESP score, may enhance outcome predictions.
  • |*Critical Illness[MESH]
  • |*Extracorporeal Membrane Oxygenation[MESH]
  • |Biomarkers/blood[MESH]
  • |COVID-19/*mortality/*therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pneumonia, Viral/*mortality/*therapy/virology[MESH]
  • |Predictive Value of Tests[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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