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10.3892/ijmm.2020.4790 http://scihub22266oqcxt.onion/10.3892/ijmm.2020.4790 33236142!7723401!33236142     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Med 2021 ; 47 (1): 326-334 Nephropedia Template TP {{tp|p=33236142|t=2021. Zinc and SARS?CoV?2: A molecular modeling study of Zn interactions with RNA?dependent RNA?polymerase and 3C?like proteinase enzymes |pdf=|usr=}}{{33236142}} gab.com Text Zinc and SARS CoV 2: A molecular modeling study of Zn interactions with RNA dependent RNA polymerase and 3C like proteinase enzymes JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33236142 #FOAvip RNA?dependent RNA?polymerase (RdRp) and 3C?like proteinase (3CLpro) are two main enzymes that play a key role in the replication of SARS?CoV?2. Zinc (Zn) has strong immunogenic properties and is known to bind to a number of proteins, modulating their activities. Zn also has a history of use in viral infection control. Thus, the present study models potential Zn binding to RdRp and the 3CLpro. Through molecular modeling, the Zn binding sites in the aforementioned two important enzymes of viral replication were found to be conserved between severe acute respiratory syndrome (SARS)?coronavirus (CoV) and SARS?CoV?2. The location of these sites may influence the enzymatic activity of 3CLpro and RdRp in coronavirus disease 2019 (COVID?19). Since Zn has established immune health benefits, is readily available, non?expensive and a safe food supplement, with the comparisons presented here between SARS?CoV and COVID?19, the present study proposes that Zn could help ameliorate the disease process of COVID?19 infection. Twit Text FOAVip Zinc and SARS CoV 2: A molecular modeling study of Zn interactions with RNA dependent RNA polymerase and 3C like proteinase enzymes ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33236142 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33236142 #FOAvip English Wikipedia <ref>{{Cite pmid|33236142}}</ref> Zinc and SARS?CoV?2: A molecular modeling study of Zn interactions with RNA?dependent RNA?polymerase and 3C?like proteinase enzymes #MMPMID33236142 Pormohammad A; Monych NK; Turner RJ Int J Mol Med 2021[Jan]; 47 (1): 326-334 PMID33236142show ga RNA?dependent RNA?polymerase (RdRp) and 3C?like proteinase (3CLpro) are two main enzymes that play a key role in the replication of SARS?CoV?2. Zinc (Zn) has strong immunogenic properties and is known to bind to a number of proteins, modulating their activities. Zn also has a history of use in viral infection control. Thus, the present study models potential Zn binding to RdRp and the 3CLpro. Through molecular modeling, the Zn binding sites in the aforementioned two important enzymes of viral replication were found to be conserved between severe acute respiratory syndrome (SARS)?coronavirus (CoV) and SARS?CoV?2. The location of these sites may influence the enzymatic activity of 3CLpro and RdRp in coronavirus disease 2019 (COVID?19). Since Zn has established immune health benefits, is readily available, non?expensive and a safe food supplement, with the comparisons presented here between SARS?CoV and COVID?19, the present study proposes that Zn could help ameliorate the disease process of COVID?19 infection. |*Models, Molecular[MESH] |Binding Sites[MESH] |COVID-19/metabolism[MESH] |Coronavirus 3C Proteases/*chemistry/metabolism[MESH] |Coronavirus RNA-Dependent RNA Polymerase/*chemistry/metabolism[MESH] |SARS-CoV-2/*chemistry/physiology[MESH] |Virus Replication[MESH]Zinc and SARS?CoV?2: A molecular modeling study of Zn interactions wit(epmc).pdf DeepDyve Pubget Overpricing