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10.1038/s41590-020-00835-8 http://scihub22266oqcxt.onion/10.1038/s41590-020-00835-8 33235385!7790436!33235385     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2021 ; 22 (1): 86-98 Nephropedia Template TP {{tp|p=33235385|t=2021. Establishment of an African green monkey model for COVID-19 and protection against re-infection |pdf=|usr=}}{{33235385}} gab.com Text Establishment of an African green monkey model for COVID-19 and protection against re-infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33235385 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species. SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure. Marked inflammation and coagulopathy in blood and tissues were prominent features. Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood. Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain. These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures. Twit Text FOAVip Establishment of an African green monkey model for COVID-19 and protection against re-infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33235385 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33235385 #FOAvip English Wikipedia <ref>{{Cite pmid|33235385}}</ref> Establishment of an African green monkey model for COVID-19 and protection against re-infection #MMPMID33235385 Woolsey C; Borisevich V; Prasad AN; Agans KN; Deer DJ; Dobias NS; Heymann JC; Foster SL; Levine CB; Medina L; Melody K; Geisbert JB; Fenton KA; Geisbert TW; Cross RW Nat Immunol 2021[Jan]; 22 (1): 86-98 PMID33235385show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to screen vaccines and treatments. We show that African green monkeys (AGMs) support robust SARS-CoV-2 replication and develop pronounced respiratory disease, which may more accurately reflect human COVID-19 cases than other nonhuman primate species. SARS-CoV-2 was detected in mucosal samples, including rectal swabs, as late as 15 days after exposure. Marked inflammation and coagulopathy in blood and tissues were prominent features. Transcriptome analysis demonstrated stimulation of interferon and interleukin-6 pathways in bronchoalveolar lavage samples and repression of natural killer cell- and T cell-associated transcripts in peripheral blood. Despite a slight waning in antibody titers after primary challenge, enhanced antibody and cellular responses contributed to rapid clearance after re-challenge with an identical strain. These data support the utility of AGM for studying COVID-19 pathogenesis and testing medical countermeasures. |*Disease Models, Animal[MESH] |Animals[MESH] |Antibodies, Viral/immunology[MESH] |COVID-19/epidemiology/*immunology/virology[MESH] |Chlorocebus aethiops[MESH] |Epidemics/prevention & control[MESH] |Gene Expression Profiling[MESH] |Gene Expression/genetics/immunology[MESH] |Humans[MESH] |Interferons/genetics/immunology/metabolism[MESH] |Killer Cells, Natural/immunology/metabolism[MESH] |Reinfection/*immunology/virology[MESH] |SARS-CoV-2/*immunology/physiology[MESH]Establishment of an African green monkey model for COVID-19 and protec(epmc).pdf DeepDyve Pubget Overpricing