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10.1126/scisignal.aba9902 http://scihub22266oqcxt.onion/10.1126/scisignal.aba9902 33234691!7857416!33234691     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2020 ; 13 (659): ä Nephropedia Template TP {{tp|p=33234691|t=2020. Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1 |pdf=|usr=}}{{33234691}} gab.com Text Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1 JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=33234691 #FOAvip Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but an in vitro model for viral replication is lacking. An interaction between the coronaviral spike (S) protein and its receptor is the primary determinant of tissue and host specificity; however, viral entry is a complex process requiring the concerted action of multiple cellular elements. Here, we found that the protease kallikrein 13 (KLK13) was required for the infection of human respiratory epithelial cells and was sufficient to mediate the entry of HCoV-HKU1 into nonpermissive RD cells. We also demonstrated the cleavage of the HCoV-HKU1 S protein by KLK13 in the S1/S2 region, suggesting that KLK13 is the priming enzyme for this virus. Together, these data suggest that protease distribution and specificity determine the tissue and cell specificity of the virus and may also regulate interspecies transmission. Twit Text FOAVip Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1 ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=33234691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33234691 #FOAvip English Wikipedia <ref>{{Cite pmid|33234691}}</ref> Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1 #MMPMID33234691 Milewska A; Falkowski K; Kulczycka M; Bielecka E; Naskalska A; Mak P; Lesner A; Ochman M; Urlik M; Diamandis E; Prassas I; Potempa J; Kantyka T; Pyrc K Sci Signal 2020[Nov]; 13 (659): ä PMID33234691show ga Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but an in vitro model for viral replication is lacking. An interaction between the coronaviral spike (S) protein and its receptor is the primary determinant of tissue and host specificity; however, viral entry is a complex process requiring the concerted action of multiple cellular elements. Here, we found that the protease kallikrein 13 (KLK13) was required for the infection of human respiratory epithelial cells and was sufficient to mediate the entry of HCoV-HKU1 into nonpermissive RD cells. We also demonstrated the cleavage of the HCoV-HKU1 S protein by KLK13 in the S1/S2 region, suggesting that KLK13 is the priming enzyme for this virus. Together, these data suggest that protease distribution and specificity determine the tissue and cell specificity of the virus and may also regulate interspecies transmission. |*Coronavirus Infections/enzymology/genetics/pathology[MESH] |*Epithelial Cells/enzymology/pathology/virology[MESH] |*Respiratory Mucosa/enzymology/pathology/virology[MESH] |Betacoronavirus/genetics/*metabolism[MESH] |Cell Line, Tumor[MESH] |Humans[MESH] |Kallikreins/genetics/*metabolism[MESH]Kallikrein 13 serves as a priming protease during infection by the hum(epmc).pdf DeepDyve Pubget Overpricing