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10.1016/j.rvsc.2020.11.009 http://scihub22266oqcxt.onion/10.1016/j.rvsc.2020.11.009 33234322!ä!33234322 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33234322&cmd=llinks): Failed to open stream: HTTP request failed! 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Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis |pdf=|usr=}}{{33234322}} gab.com Text Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis JO: Res Vet Sci http://www.kidney.de/pget.php?&tw=1&pmid=33234322 #FOAvip Forsythoside A is the main active ingredient in the Chinese medicine Forsythia suspensa, which has antiviral, anti-inflammatory, antioxidation, and immunoregulatory effects. It is reported that Forsythoside A can significantly inhibit the replication of the avian infectious bronchitis virus(IBV) in cells, but there is no report in chickens. The present study aimed to investigate the effect of Forsythoside A on IBV-M41, experiments were designed using 120 chickens at 12 days of age. The chickens were randomly divided into eight groups: Forsythoside A high-, medium-, and low-dose prevention groups, Forsythoside A high-, medium-, and low-dose treatment groups, model control group and normal control group. All chickens, except the normal control group, were inoculated with 0.2 ml of IBV-M41 at 15 days of age.The antiviral effects were evaluated by clinical signs, weight, histopathology, T-,B-lymphocyte proliferation, T-lymphocyte subsets and cytokine levels.The results showed that the infection rate in each Forsythoside A prevention group was significantly lower than that in the treatment group and model control group (P < 0.05). The recovery rate in each Forsythoside A treatment group was significantly higher than that in the model control group (P < 0.05), and the recovery rate in high- and medium-dose treatment group was the highest, at up to 86.67%. Lymphocytic transformation ability significantly improved in the prevention and treatment groups. Forsythoside A significantly improved the CD3+, CD4+, and CD8+ T-lymphocyte of infected chickens. The cytokine level was able to maintain high concentrations of IL-2 and IFN-alpha for a long time and maintain a dynamic IL-4-concentration balance. A number of results showed that Forsythoside A had both preventive and therapeutic effects in IBV-M41-infected chickens, among which the high-dose (80 mg/kg/d) prevention group?the high- (80 mg/kg/d) and medium (40 mg/kg/d) -dose treatment group had significant effects. Twit Text FOAVip Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis ????Res Vet Sci http://www.kidney.de/pget.php?&tw=1&pmid=33234322 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33234322 #FOAvip English Wikipedia <ref>{{Cite pmid|33234322}}</ref> Experimental study of Forsythoside A on prevention and treatment of avian infectious bronchitis #MMPMID33234322 Wang X; Li X; Wang X; Chen L; Ning E; Fan Y; Wang H; Chen T; Wang W Res Vet Sci 2021[Mar]; 135 (ä): 523-531 PMID33234322show ga Forsythoside A is the main active ingredient in the Chinese medicine Forsythia suspensa, which has antiviral, anti-inflammatory, antioxidation, and immunoregulatory effects. It is reported that Forsythoside A can significantly inhibit the replication of the avian infectious bronchitis virus(IBV) in cells, but there is no report in chickens. The present study aimed to investigate the effect of Forsythoside A on IBV-M41, experiments were designed using 120 chickens at 12 days of age. The chickens were randomly divided into eight groups: Forsythoside A high-, medium-, and low-dose prevention groups, Forsythoside A high-, medium-, and low-dose treatment groups, model control group and normal control group. All chickens, except the normal control group, were inoculated with 0.2 ml of IBV-M41 at 15 days of age.The antiviral effects were evaluated by clinical signs, weight, histopathology, T-,B-lymphocyte proliferation, T-lymphocyte subsets and cytokine levels.The results showed that the infection rate in each Forsythoside A prevention group was significantly lower than that in the treatment group and model control group (P < 0.05). The recovery rate in each Forsythoside A treatment group was significantly higher than that in the model control group (P < 0.05), and the recovery rate in high- and medium-dose treatment group was the highest, at up to 86.67%. Lymphocytic transformation ability significantly improved in the prevention and treatment groups. Forsythoside A significantly improved the CD3+, CD4+, and CD8+ T-lymphocyte of infected chickens. The cytokine level was able to maintain high concentrations of IL-2 and IFN-alpha for a long time and maintain a dynamic IL-4-concentration balance. A number of results showed that Forsythoside A had both preventive and therapeutic effects in IBV-M41-infected chickens, among which the high-dose (80 mg/kg/d) prevention group?the high- (80 mg/kg/d) and medium (40 mg/kg/d) -dose treatment group had significant effects. |*Chickens[MESH] |*Infectious bronchitis virus[MESH] |Animals[MESH] |Antiviral Agents/pharmacology[MESH] |Bronchitis/drug therapy/*veterinary[MESH] |Coronavirus Infections/drug therapy/prevention & control/*veterinary[MESH] |Cytokines[MESH] |Drugs, Chinese Herbal[MESH] |Glycosides/*therapeutic use[MESH]Experimental study of Forsythoside A on prevention and treatment of av(epmc).pdf DeepDyve Pubget Overpricing