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10.1016/bs.ircmb.2020.09.003 http://scihub22266oqcxt.onion/10.1016/bs.ircmb.2020.09.003 33234246!ä!33234246 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+Rev+Cell+Mol+Biol 2020 ; 357 (ä): 81-122 Nephropedia Template TP {{tp|p=33234246|t=2020. TAM receptors: A phosphatidylserine receptor family and its implications in viral infections |pdf=|usr=}}{{33234246}} gab.com Text TAM receptors: A phosphatidylserine receptor family and its implications in viral infections JO: Int Rev Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33234246 #FOAvip Phosphatidylserine (PS) is an anionic phospholipid that is usually localized in the inner leaflets of the plasma membrane. However, the enzyme scramblase catalyzes the externalization of PS on the outer leaflet of the plasma membrane during apoptosis or cellular stress. This event prompts the recognition of PS displaying cells by phagocytes leading to "apoptotic clearance." Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1. Ironically, this network (PS/TAM) that evolved for boosting cellular health through clearance of apoptotic and necrotic cells, has been manoeuvred by pathogens and tumor cells using "apoptotic mimicry." Enveloped viruses, responsible for most of the lethal epidemics and pandemics including the current SARS-CoV2 outbreak, have employed apoptotic mimicry to their advantage. In the current chapter, we summarize the existing knowledge regarding the involvement of PS/Gas6, ProS1/TAM in facilitating infectivity in a diverse set of cell lines, animals as well as organoids. This network executes a largely proviral role in facilitating infection as seen with Zika, Ebola, Influenza and Dengue viruses. However, this response varies with strains and the cells infected, and in some cases, this same signaling displays an antiviral function. We also report multiple studies that have used neutralizing antibodies and small molecule inhibitors in successfully reducing viral replication and ameliorating pathogenicity. Knowledge about this unique signaling pathway and measures that can be taken to inhibit it is most valuable now given how enveloped viruses lead to plagues on the entire globe. Twit Text FOAVip TAM receptors: A phosphatidylserine receptor family and its implications in viral infections ????Int Rev Cell Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=33234246 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33234246 #FOAvip English Wikipedia <ref>{{Cite pmid|33234246}}</ref> TAM receptors: A phosphatidylserine receptor family and its implications in viral infections #MMPMID33234246 Ghosh Roy S Int Rev Cell Mol Biol 2020[]; 357 (ä): 81-122 PMID33234246show ga Phosphatidylserine (PS) is an anionic phospholipid that is usually localized in the inner leaflets of the plasma membrane. However, the enzyme scramblase catalyzes the externalization of PS on the outer leaflet of the plasma membrane during apoptosis or cellular stress. This event prompts the recognition of PS displaying cells by phagocytes leading to "apoptotic clearance." Multiple PS receptors (PSRs) mediate this process including members from the TAM (Tyro3, Axl, Mertk) receptor Tyrosine kinases (RTKs) by interacting with PS via bridging proteins like Gas6 and ProS1. Ironically, this network (PS/TAM) that evolved for boosting cellular health through clearance of apoptotic and necrotic cells, has been manoeuvred by pathogens and tumor cells using "apoptotic mimicry." Enveloped viruses, responsible for most of the lethal epidemics and pandemics including the current SARS-CoV2 outbreak, have employed apoptotic mimicry to their advantage. In the current chapter, we summarize the existing knowledge regarding the involvement of PS/Gas6, ProS1/TAM in facilitating infectivity in a diverse set of cell lines, animals as well as organoids. This network executes a largely proviral role in facilitating infection as seen with Zika, Ebola, Influenza and Dengue viruses. However, this response varies with strains and the cells infected, and in some cases, this same signaling displays an antiviral function. We also report multiple studies that have used neutralizing antibodies and small molecule inhibitors in successfully reducing viral replication and ameliorating pathogenicity. Knowledge about this unique signaling pathway and measures that can be taken to inhibit it is most valuable now given how enveloped viruses lead to plagues on the entire globe. |*Signal Transduction[MESH] |Animals[MESH] |Axl Receptor Tyrosine Kinase[MESH] |Humans[MESH] |Intercellular Signaling Peptides and Proteins/metabolism[MESH] |Protein S/metabolism[MESH] |Proto-Oncogene Proteins/*metabolism[MESH] |RNA Virus Infections/*metabolism[MESH] |RNA Viruses/*metabolism[MESH] |Receptor Protein-Tyrosine Kinases/*metabolism[MESH] |Receptors, Cell Surface/*metabolism[MESH]TAM receptors: A phosphatidylserine receptor family and its implicatio(epmc).pdf DeepDyve Pubget Overpricing