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10.1016/j.bbrc.2020.10.092

http://scihub22266oqcxt.onion/10.1016/j.bbrc.2020.10.092
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33234239!7643664!33234239
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suck abstract from ncbi

pmid33234239      Biochem+Biophys+Res+Commun 2021 ; 538 (ä): 35-39
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  • Host-directed editing of the SARS-CoV-2 genome #MMPMID33234239
  • Mourier T; Sadykov M; Carr MJ; Gonzalez G; Hall WW; Pain A
  • Biochem Biophys Res Commun 2021[Jan]; 538 (ä): 35-39 PMID33234239show ga
  • The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
  • |*Gene Editing[MESH]
  • |*Genome, Viral[MESH]
  • |APOBEC Deaminases/*metabolism[MESH]
  • |Adenosine Deaminase/*metabolism[MESH]
  • |COVID-19/epidemiology/*virology[MESH]
  • |Host-Pathogen Interactions/*genetics[MESH]
  • |Humans[MESH]
  • |RNA-Binding Proteins/*metabolism[MESH]
  • |Reactive Oxygen Species/metabolism[MESH]


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