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10.1016/j.stem.2020.11.009 http://scihub22266oqcxt.onion/10.1016/j.stem.2020.11.009 33232663!7670929!33232663     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2020 ; 27 (6): 876-889.e12 Nephropedia Template TP {{tp|p=33232663|t=2020. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men |pdf=|usr=}}{{33232663}} gab.com Text Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=33232663 #FOAvip SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the disease and potential treatment options remains limited. The infection occurs through binding of the virus with angiotensin converting enzyme 2 (ACE2) on the cell membrane. Here, we established a screening strategy to identify drugs that reduce ACE2 levels in human embryonic stem cell (hESC)-derived cardiac cells and lung organoids. Target analysis of hit compounds revealed androgen signaling as a key modulator of ACE2 levels. Treatment with antiandrogenic drugs reduced ACE2 expression and protected hESC-derived lung organoids against SARS-CoV-2 infection. Finally, clinical data on COVID-19 patients demonstrated that prostate diseases, which are linked to elevated androgen, are significant risk factors and that genetic variants that increase androgen levels are associated with higher disease severity. These findings offer insights on the mechanism of disproportionate disease susceptibility in men and identify antiandrogenic drugs as candidate therapeutics for COVID-19. Twit Text FOAVip Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=33232663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33232663 #FOAvip English Wikipedia <ref>{{Cite pmid|33232663}}</ref> Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men #MMPMID33232663 Samuel RM; Majd H; Richter MN; Ghazizadeh Z; Zekavat SM; Navickas A; Ramirez JT; Asgharian H; Simoneau CR; Bonser LR; Koh KD; Garcia-Knight M; Tassetto M; Sunshine S; Farahvashi S; Kalantari A; Liu W; Andino R; Zhao H; Natarajan P; Erle DJ; Ott M; Goodarzi H; Fattahi F Cell Stem Cell 2020[Dec]; 27 (6): 876-889.e12 PMID33232663show ga SARS-CoV-2 infection has led to a global health crisis, and yet our understanding of the disease and potential treatment options remains limited. The infection occurs through binding of the virus with angiotensin converting enzyme 2 (ACE2) on the cell membrane. Here, we established a screening strategy to identify drugs that reduce ACE2 levels in human embryonic stem cell (hESC)-derived cardiac cells and lung organoids. Target analysis of hit compounds revealed androgen signaling as a key modulator of ACE2 levels. Treatment with antiandrogenic drugs reduced ACE2 expression and protected hESC-derived lung organoids against SARS-CoV-2 infection. Finally, clinical data on COVID-19 patients demonstrated that prostate diseases, which are linked to elevated androgen, are significant risk factors and that genetic variants that increase androgen levels are associated with higher disease severity. These findings offer insights on the mechanism of disproportionate disease susceptibility in men and identify antiandrogenic drugs as candidate therapeutics for COVID-19. |*Patient Acuity[MESH] |*Signal Transduction[MESH] |Adult[MESH] |Androgen Antagonists[MESH] |Androgens/*metabolism/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Animals[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/complications/*metabolism[MESH] |Cells, Cultured[MESH] |Chlorocebus aethiops[MESH] |Drug Evaluation, Preclinical[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Myocytes, Cardiac/drug effects/metabolism[MESH] |Organoids/drug effects/virology[MESH] |Receptors, Coronavirus/*metabolism[MESH] |Risk Factors[MESH] |Sex Factors[MESH]Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associa(epmc).pdf DeepDyve Pubget Overpricing