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10.18632/aging.202172

http://scihub22266oqcxt.onion/10.18632/aging.202172
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33232277!7746365!33232277
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suck abstract from ncbi


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pmid33232277      Aging+(Albany+NY) 2020 ; 12 (22): 22413-22424
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  • Estimating the release of inflammatory factors and use of glucocorticoid therapy for COVID-19 patients with comorbidities #MMPMID33232277
  • Han D; Peng C; Meng R; Yao J; Zhou Q; Xiao Y; Ma H
  • Aging (Albany NY) 2020[Nov]; 12 (22): 22413-22424 PMID33232277show ga
  • COVID-19 exhibits both variability and rapid progression, particularly in patients with comorbidities such as diabetes, hypertension or cancer. To determine how these underlying disorders exacerbate pneumonia in COVID-19, we evaluated 79 patients with severe COVID-19 and grouped them according to whether or not they had comorbidities. Clinical information, laboratory examinations, immunological function, and treatment outcomes were retrospectively analyzed. Our study revealed that severe COVID-19 patients with comorbidities had higher levels of inflammatory indices, including blood interferon-gamma, interleukin (IL)-6 and c-reactive protein levels as well as the erythrocyte sedimentation rate. These were accompanied by lymphopenia, hypokalemia, hypoalbuminemia, a decrease in either CD4+ T cells or lymphocyte count, and coagulation disorders, which were closely related to poor prognosis. Patients with comorbidities also had longer disease remission times (27 +/- 6.7 days) than those without comorbidities (20 +/- 6.5 days). Cox multivariate analysis indicated that glucocorticoid therapy and IL-6 were independent prognostic factors. Our findings suggest that coexisting comorbidities aggravate COVID-19 through the excessive release of inflammatory factors and that glucocorticoid therapy may be beneficial.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Blood Sedimentation[MESH]
  • |C-Reactive Protein/analysis/immunology[MESH]
  • |CD4 Lymphocyte Count[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/blood/epidemiology/*immunology[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Glucocorticoids/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Inflammation Mediators/*blood[MESH]
  • |Inflammation/blood/*diagnosis/drug therapy/immunology[MESH]
  • |Interleukin-6/blood/immunology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Prognosis[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*immunology/isolation & purification[MESH]
  • |Severity of Illness Index[MESH]


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