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10.1084/jem.20201707 http://scihub22266oqcxt.onion/10.1084/jem.20201707 33231615!7684031!33231615     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Med 2021 ; 218 (3): ä Nephropedia Template TP {{tp|p=33231615|t=2021. Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients |pdf=|usr=}}{{33231615}} gab.com Text Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33231615 #FOAvip Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Casp1p20), IL-1beta, and IL-18. Although participation of the inflammasome in COVID-19 has been highly speculated, the inflammasome activation and participation in the outcome of the disease are unknown. Here we demonstrate that the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection and is active in COVID-19 patients. Studying moderate and severe COVID-19 patients, we found active NLRP3 inflammasome in PBMCs and tissues of postmortem patients upon autopsy. Inflammasome-derived products such as Casp1p20 and IL-18 in the sera correlated with the markers of COVID-19 severity, including IL-6 and LDH. Moreover, higher levels of IL-18 and Casp1p20 are associated with disease severity and poor clinical outcome. Our results suggest that inflammasomes participate in the pathophysiology of the disease, indicating that these platforms might be a marker of disease severity and a potential therapeutic target for COVID-19. Twit Text FOAVip Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=33231615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33231615 #FOAvip English Wikipedia <ref>{{Cite pmid|33231615}}</ref> Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients #MMPMID33231615 Rodrigues TS; de Sa KSG; Ishimoto AY; Becerra A; Oliveira S; Almeida L; Goncalves AV; Perucello DB; Andrade WA; Castro R; Veras FP; Toller-Kawahisa JE; Nascimento DC; de Lima MHF; Silva CMS; Caetite DB; Martins RB; Castro IA; Pontelli MC; de Barros FC; do Amaral NB; Giannini MC; Bonjorno LP; Lopes MIF; Santana RC; Vilar FC; Auxiliadora-Martins M; Luppino-Assad R; de Almeida SCL; de Oliveira FR; Batah SS; Siyuan L; Benatti MN; Cunha TM; Alves-Filho JC; Cunha FQ; Cunha LD; Frantz FG; Kohlsdorf T; Fabro AT; Arruda E; de Oliveira RDR; Louzada-Junior P; Zamboni DS J Exp Med 2021[Mar]; 218 (3): ä PMID33231615show ga Severe cases of COVID-19 are characterized by a strong inflammatory process that may ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular platform that promotes inflammation via cleavage and activation of key inflammatory molecules including active caspase-1 (Casp1p20), IL-1beta, and IL-18. Although participation of the inflammasome in COVID-19 has been highly speculated, the inflammasome activation and participation in the outcome of the disease are unknown. Here we demonstrate that the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection and is active in COVID-19 patients. Studying moderate and severe COVID-19 patients, we found active NLRP3 inflammasome in PBMCs and tissues of postmortem patients upon autopsy. Inflammasome-derived products such as Casp1p20 and IL-18 in the sera correlated with the markers of COVID-19 severity, including IL-6 and LDH. Moreover, higher levels of IL-18 and Casp1p20 are associated with disease severity and poor clinical outcome. Our results suggest that inflammasomes participate in the pathophysiology of the disease, indicating that these platforms might be a marker of disease severity and a potential therapeutic target for COVID-19. |*Severity of Illness Index[MESH] |Apoptosis[MESH] |COVID-19/*pathology/*virology[MESH] |Comorbidity[MESH] |Cytokines/biosynthesis[MESH] |Humans[MESH] |Inflammasomes/*metabolism[MESH] |Lung/pathology[MESH] |Monocytes/metabolism[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/metabolism[MESH] |Postmortem Changes[MESH] |SARS-CoV-2/*physiology[MESH]Inflammasomes are activated in response to SARS-CoV-2 infection and ar(epmc).pdf DeepDyve Pubget Overpricing