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Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking Studies Unveil an Opportunity Against CORONA |pdf=|usr=}}{{33231155}} gab.com Text Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking Studies Unveil an Opportunity Against CORONA JO: Comb Chem High Throughput Screen http://www.kidney.de/pget.php?&tw=1&pmid=33231155 #FOAvip BACKGROUND: A newly emergent strain of coronavirus (COVID-19) has affected almost the whole of the world's population. Currently, there is no specific vaccine or drug against COVID-19. Xu et al. (2020) built a homolog model of SARS-CoV-2 Mpro based on SARS-CoV Mpro, which is considered as a target to inhibit the replication of CoV. OBJECTIVE: The aim of the current study was to find potential inhibitors of COVID-19 Mpro using docking analysis. METHODS: Autodockvina was used to carry out Protein-Ligand docking. COVID-19 main protease Mpro was docked with catechin and its different synthetic derivatives. Nelfinavir, an antiretroviral drug belonging to protease inhibitors, was taken as the standard. RESULTS: According to the result obtained, it was found that Compound (4) and Compound (1) have more affinity than nelfinavir. CONCLUSION: Compounds were found to have a great potential to become COVID-19 main protease Mpro inhibitor. Nevertheless, for their medicinal use, further investigation is necessary. Twit Text FOAVip Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking Studies Unveil an Opportunity Against CORONA ????Comb Chem High Throughput Screen http://www.kidney.de/pget.php?&tw=1&pmid=33231155 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33231155 #FOAvip English Wikipedia <ref>{{Cite pmid|33231155}}</ref> Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Molecular Docking Studies Unveil an Opportunity Against CORONA #MMPMID33231155 Arif MN Comb Chem High Throughput Screen 2022[]; 25 (1): 197-203 PMID33231155show ga BACKGROUND: A newly emergent strain of coronavirus (COVID-19) has affected almost the whole of the world's population. Currently, there is no specific vaccine or drug against COVID-19. Xu et al. (2020) built a homolog model of SARS-CoV-2 Mpro based on SARS-CoV Mpro, which is considered as a target to inhibit the replication of CoV. OBJECTIVE: The aim of the current study was to find potential inhibitors of COVID-19 Mpro using docking analysis. METHODS: Autodockvina was used to carry out Protein-Ligand docking. COVID-19 main protease Mpro was docked with catechin and its different synthetic derivatives. Nelfinavir, an antiretroviral drug belonging to protease inhibitors, was taken as the standard. RESULTS: According to the result obtained, it was found that Compound (4) and Compound (1) have more affinity than nelfinavir. CONCLUSION: Compounds were found to have a great potential to become COVID-19 main protease Mpro inhibitor. Nevertheless, for their medicinal use, further investigation is necessary. |*Antiviral Agents/pharmacology[MESH] |*Catechin/pharmacology[MESH] |*Protease Inhibitors/pharmacology[MESH] |COVID-19[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH]Catechin Derivatives as Inhibitor of COVID-19 Main Protease (Mpro): Mo(epmc).pdf DeepDyve Pubget Overpricing