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Vitamin and mineral supplementation for beta-thalassemia during COVID-19 pandemic #MMPMID33230422
d'Arqom A; G Putri M; Savitri Y; Rahul Alfaidin AM
Future Sci OA 2020[Aug]; 6 (9): FSO628 PMID33230422show ga
AIM: Low levels of immune-related micronutrients have been identified in beta-thalassemia samples. Moreover, the excess amount of iron, contributing to oxidative stress in the pathogenesis of the disease, alters the immune system in beta-thalassemia, which is important during the COVID-19 pandemic. MATERIALS & METHODS: Searches of PUBMED and EMBASE were conducted to identify the level and supplementation of micronutrients in beta-thalassemia, published from 2001-May 2020. RESULTS: The review found six observational and five interventional studies supporting the importance of supplementing vitamins and minerals among patients with beta-thalassemia. CONCLUSION: Supplementation of immune-related vitamins and minerals might bring benefits to the immune system, especially in reducing oxidative stress in beta-thalassemia.