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10.1038/s41598-020-76702-1 http://scihub22266oqcxt.onion/10.1038/s41598-020-76702-1 33230147!7683603!33230147     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 20363 Nephropedia Template TP {{tp|p=33230147|t=2020. Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells |pdf=|usr=}}{{33230147}} gab.com Text Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33230147 #FOAvip Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activation of CD8+ T cells by targeting CD4+ T cells. When autologous OCs were used to expand patient NK cells much lower percentages of expanded CD8+ T cells, decreased numbers of expanded NK cells and decreased functions of NK cells could be observed, and the addition of allogeneic healthy OCs increased the patients' NK function. Mechanistically, OC-expanded NK cells were found to lyse CD4+ T cells but not CD8+ T cells suggesting potential selection of CD8+ T cells before their expansion by OC activated NK cells. In agreement, Increased IFN-gamma secretion, and NK cell-mediated cytotoxicity and higher percentages of CD8+ T cells, in various tissue compartments of oral tumor-bearing hu-BLT mice in response to immunotherapy by OC-expanded NK cells were observed. Thus, our results indicate an important relationship between NK and CD8+ T cells. Twit Text FOAVip Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33230147 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33230147 #FOAvip English Wikipedia <ref>{{Cite pmid|33230147}}</ref> Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells #MMPMID33230147 Kaur K; Ko MW; Ohanian N; Cook J; Jewett A Sci Rep 2020[Nov]; 10 (1): 20363 PMID33230147show ga Osteoclasts (OCs) and much less dendritic cells (DCs) induce significant expansion and functional activation of NK cells, and furthermore, the OC-expanded NK cells preferentially increase the expansion and activation of CD8+ T cells by targeting CD4+ T cells. When autologous OCs were used to expand patient NK cells much lower percentages of expanded CD8+ T cells, decreased numbers of expanded NK cells and decreased functions of NK cells could be observed, and the addition of allogeneic healthy OCs increased the patients' NK function. Mechanistically, OC-expanded NK cells were found to lyse CD4+ T cells but not CD8+ T cells suggesting potential selection of CD8+ T cells before their expansion by OC activated NK cells. In agreement, Increased IFN-gamma secretion, and NK cell-mediated cytotoxicity and higher percentages of CD8+ T cells, in various tissue compartments of oral tumor-bearing hu-BLT mice in response to immunotherapy by OC-expanded NK cells were observed. Thus, our results indicate an important relationship between NK and CD8+ T cells. |*Cytotoxicity, Immunologic[MESH] |Animals[MESH] |CD4-Positive T-Lymphocytes/immunology/pathology[MESH] |CD8-Positive T-Lymphocytes/immunology/pathology[MESH] |Carcinoma, Squamous Cell/immunology/pathology/*therapy[MESH] |Cell Communication/immunology[MESH] |Cell Proliferation[MESH] |Coculture Techniques[MESH] |Dendritic Cells/immunology/pathology[MESH] |Humans[MESH] |Immunophenotyping[MESH] |Immunotherapy/*methods[MESH] |Interferon-gamma/biosynthesis/immunology[MESH] |Killer Cells, Natural/*immunology/pathology/transplantation[MESH] |Lymphocyte Activation[MESH] |Lymphocyte Count[MESH] |Mice[MESH] |Mice, Transgenic[MESH] |Mouth Neoplasms/immunology/pathology/*therapy[MESH] |Osteoclasts/*immunology/pathology[MESH] |Primary Cell Culture[MESH]Osteoclast-expanded super-charged NK-cells preferentially select and e(epmc).pdf DeepDyve Pubget Overpricing