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10.1080/08820139.2020.1851709 http://scihub22266oqcxt.onion/10.1080/08820139.2020.1851709 33228423!7711738!33228423     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Invest 2022 ; 51 (3): 546-557 Nephropedia Template TP {{tp|p=33228423|t=2022. Association of TNF-alpha G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients |pdf=|usr=}}{{33228423}} gab.com Text Association of TNF-alpha G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients JO: Immunol Invest http://www.kidney.de/pget.php?&tw=1&pmid=33228423 #FOAvip BACKGROUND: Tumor necrosis factor-a (TNF-a) is one of the most important cytokines that manage the host defense mechanism, which may play a role in the pathogenesis of COVID-19 patients. The work aims to study the association of TNF-a G-308 A gene polymorphism with the course and outcome of COVID-19 patients in Mansoura University Hospital. METHODS: 900 patients with COVID-19 infection and 184 controls were tested for TNF-a G-308 A promoter polymorphism. Different genotypes of TNF-a G-308 A were compared as regards the severity and prognosis of the disease. RESULTS: No statistically significant difference was found between patients and controls as regards the demographic data. The AA genotype of TNF-a showed a higher incidence of the disease in comparison to the other genotypes. As regards the demographic and laboratory characters, no statistically significant difference was found between the different genotypes except for age, lymphopenia, CRP, and serum ferritin levels. In 336(80.0%) cases of the AA genotype, the disease was severe in comparison to 90(41.7%) cases in the GA genotype and no cases in the GG genotype with P = .001. CONCLUSION: People who carry the A allele of TNF-a polymorphism are more prone to COVID-19 infection. The AA genotype of TNF-a is associated with a more aggressive pattern of the disease. In those patients, the use of anti - TNF therapy may be promising. Twit Text FOAVip Association of TNF-alpha G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients ????Immunol Invest http://www.kidney.de/pget.php?&tw=1&pmid=33228423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33228423 #FOAvip English Wikipedia <ref>{{Cite pmid|33228423}}</ref> Association of TNF-alpha G-308 a Promoter Polymorphism with the Course and Outcome of COVID-19 Patients #MMPMID33228423 Saleh A; Sultan A; Elashry MA; Farag A; Mortada MI; Ghannam MA; Saed AM; Ghoneem E Immunol Invest 2022[Apr]; 51 (3): 546-557 PMID33228423show ga BACKGROUND: Tumor necrosis factor-a (TNF-a) is one of the most important cytokines that manage the host defense mechanism, which may play a role in the pathogenesis of COVID-19 patients. The work aims to study the association of TNF-a G-308 A gene polymorphism with the course and outcome of COVID-19 patients in Mansoura University Hospital. METHODS: 900 patients with COVID-19 infection and 184 controls were tested for TNF-a G-308 A promoter polymorphism. Different genotypes of TNF-a G-308 A were compared as regards the severity and prognosis of the disease. RESULTS: No statistically significant difference was found between patients and controls as regards the demographic data. The AA genotype of TNF-a showed a higher incidence of the disease in comparison to the other genotypes. As regards the demographic and laboratory characters, no statistically significant difference was found between the different genotypes except for age, lymphopenia, CRP, and serum ferritin levels. In 336(80.0%) cases of the AA genotype, the disease was severe in comparison to 90(41.7%) cases in the GA genotype and no cases in the GG genotype with P = .001. CONCLUSION: People who carry the A allele of TNF-a polymorphism are more prone to COVID-19 infection. The AA genotype of TNF-a is associated with a more aggressive pattern of the disease. In those patients, the use of anti - TNF therapy may be promising. |*COVID-19/genetics[MESH] |*Tumor Necrosis Factor-alpha/genetics[MESH] |Case-Control Studies[MESH] |Genetic Predisposition to Disease[MESH] |Genotype[MESH] |Humans[MESH] |Polymorphism, Single Nucleotide[MESH]Association of TNF-alpha G-308 a Promoter Polymorphism with the Course(epmc).pdf DeepDyve Pubget Overpricing