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10.1016/j.jviromet.2020.114024

http://scihub22266oqcxt.onion/10.1016/j.jviromet.2020.114024
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33227341!7678421!33227341
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suck abstract from ncbi


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pmid33227341      J+Virol+Methods 2021 ; 288 (ä): 114024
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  • Comparison of the SARS-CoV-2 Rapid antigen test to the real star Sars-CoV-2 RT PCR kit #MMPMID33227341
  • Kruttgen A; Cornelissen CG; Dreher M; Hornef MW; Imohl M; Kleines M
  • J Virol Methods 2021[Feb]; 288 (ä): 114024 PMID33227341show ga
  • There is an ongoing need for reliable antigen assays for timely and easy detection of individuals with acute SARS-CoV-2 infection. Using 75 swabs from patients previously tested positive by SARS-CoV-2 PCR and 75 swabs from patients previously tested negative by SARS-CoV-2 PCR, we investigated the sensitivity and specificity of the SARS-CoV-2 Rapid Antigen Test (Roche). We determined a specificity of 96 %. The assay's sensitivity with samples with a cycle threshold of < 25, 25 - <30, 30 - <35, and> = 35 was 100 %, 95 %, 44.8 % and 22.2 %, respectively. We conclude that sensitivity and specificity of the antigen assay is inferior to the PCR assay. However, the antigen assay may be a quick and easy to perform alternative for differentiation of individuals contagious for SARS-CoV-2 from non-contagious individuals.
  • |*Immunoassay[MESH]
  • |*Reagent Kits, Diagnostic[MESH]
  • |*Reverse Transcriptase Polymerase Chain Reaction[MESH]
  • |*SARS-CoV-2/genetics/immunology[MESH]
  • |Antigens, Viral/immunology[MESH]
  • |COVID-19 Testing/*methods/standards[MESH]
  • |COVID-19/*diagnosis/virology[MESH]
  • |Humans[MESH]
  • |RNA, Viral[MESH]


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