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10.1371/journal.pone.0242651

http://scihub22266oqcxt.onion/10.1371/journal.pone.0242651
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33227024!7682899!33227024
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suck abstract from ncbi


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pmid33227024      PLoS+One 2020 ; 15 (11): e0242651
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  • Outcomes of mechanically ventilated patients with COVID-19 associated respiratory failure #MMPMID33227024
  • King CS; Sahjwani D; Brown AW; Feroz S; Cameron P; Osborn E; Desai M; Djurkovic S; Kasarabada A; Hinerman R; Lantry J; Shlobin OA; Ahmad K; Khangoora V; Aryal S; Collins AC; Speir A; Nathan S
  • PLoS One 2020[]; 15 (11): e0242651 PMID33227024show ga
  • PURPOSE: The outcomes of patients requiring invasive mechanical ventilation for COVID-19 remain poorly defined. We sought to determine clinical characteristics and outcomes of patients with COVID-19 managed with invasive mechanical ventilation in an appropriately resourced US health care system. METHODS: Outcomes of COVID-19 infected patients requiring mechanical ventilation treated within the Inova Health System between March 5, 2020 and April 26, 2020 were evaluated through an electronic medical record review. RESULTS: 1023 COVID-19 positive patients were admitted to the Inova Health System during the study period. Of these, 164 (16.0%) were managed with invasive mechanical ventilation. All patients were followed to definitive disposition. 70/164 patients (42.7%) had died and 94/164 (57.3%) were still alive. Deceased patients were older (median age of 66 vs. 55, p <0.0001) and had a higher initial d-dimer (2.22 vs. 1.31, p = 0.005) and peak ferritin levels (2998 vs. 2077, p = 0.016) compared to survivors. 84.3% of patients over 70 years old died in the hospital. Conversely, 67.4% of patients age 70 or younger survived to hospital discharge. Younger age, non-Caucasian race and treatment at a tertiary care center were all associated with survivor status. CONCLUSION: Mortality of patients with COVID-19 requiring invasive mechanical ventilation is high, with particularly daunting mortality seen in patients of advanced age, even in a well-resourced health care system. A substantial proportion of patients requiring invasive mechanical ventilation were not of advanced age, and this group had a reasonable chance for recovery.
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/blood/*complications/epidemiology/virology[MESH]
  • |Critical Care/standards[MESH]
  • |Female[MESH]
  • |Ferritins/blood[MESH]
  • |Fibrin Fibrinogen Degradation Products/analysis[MESH]
  • |Hospital Mortality[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Patient Discharge[MESH]
  • |Respiration, Artificial/*adverse effects[MESH]
  • |Respiratory Insufficiency/*etiology/*mortality[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/*genetics[MESH]
  • |Virginia/epidemiology[MESH]


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