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10.2217/fvl-2020-0188

http://scihub22266oqcxt.onion/10.2217/fvl-2020-0188
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suck abstract from ncbi


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pmid33224264      Future+Virol 2020 ; 15 (9): 577-593
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  • Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection #MMPMID33224264
  • Turjya RR; Khan MA; Mir Md Khademul Islam AB
  • Future Virol 2020[Sep]; 15 (9): 577-593 PMID33224264show ga
  • BACKGROUND: Regulatory roles of long noncoding RNAs (lncRNAs) during viral infection has become more evident in last decade, but are yet to be explored for SARS-CoV-2. MATERIALS & METHODS: We analyzed RNA-seq dataset of SARS-CoV-2 infected lung epithelial cells to identify differentially expressed genes. RESULTS: Our analyses uncover 21 differentially expressed lncRNAs broadly involved in cell survival and regulation of gene expression. These lncRNAs can directly interact with six differentially expressed protein-coding genes, and ten host genes that interact with SARS-CoV-2 proteins. Also, they can block the suppressive effect of nine microRNAs induced in viral infections. CONCLUSION: Our investigation determines that deregulated lncRNAs in SARS-CoV-2 infection are involved in viral proliferation, cellular survival, and immune response, ultimately determining disease outcome.
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