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10.1002/ejhf.2060 http://scihub22266oqcxt.onion/10.1002/ejhf.2060 33222412!7753665!33222412     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33222412&cmd=llinks): Failed to open stream: HTTP request failed! 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Association between renin-angiotensin-aldosterone system inhibitor use and COVID-19 hospitalization and death: a 1 4 million patient nationwide registry analysis |pdf=|usr=}}{{33222412}} gab.com Text Association between renin-angiotensin-aldosterone system inhibitor use and COVID-19 hospitalization and death: a 1 4 million patient nationwide registry analysis JO: Eur J Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=33222412 #FOAvip AIMS: Renin-angiotensin-aldosterone system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident hospitalization and death from coronavirus disease 2019 (COVID-19). We investigated the association between use of angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARBs) or mineralocorticoid receptor antagonists (MRAs) and COVID-19 hospitalization/death in a large nationwide population. METHODS AND RESULTS: Patients with hypertension, heart failure, diabetes, kidney disease, or ischaemic heart disease registered in the Swedish National Patient Registry until 1 February 2020 were included and followed until 31 May 2020. COVID-19 cases were defined based on hospitalization/death for COVID-19. Multivariable logistic and Cox regressions were fitted to investigate the association between ACEi/ARB and MRA and risk of hospitalization/death for COVID-19 in the overall population, and of all-cause mortality in COVID-19 cases. We performed consistency analysis to quantify the impact of potential unmeasured confounding. Of 1 387 746 patients (60% receiving ACEi/ARB and 5.8% MRA), 7146 (0.51%) had incident hospitalization/death from COVID-19. After adjustment for 45 variables, ACEi/ARB use was associated with a reduced risk of hospitalization/death for COVID-19 (odds ratio 0.86, 95% confidence interval 0.81-0.91) in the overall population, and with reduced mortality in COVID-19 cases (hazard ratio 0.89, 95% confidence interval 0.82-0.96). MRA use was not associated with risk of any outcome. Consistency analysis showed that unmeasured confounding would need to be large for there to be harmful signals associated with RAASi use. CONCLUSIONS: In a 1.4 million nationwide cohort, use of RAASi was not associated with increased risk of hospitalization for or death from COVID-19. Twit Text FOAVip Association between renin-angiotensin-aldosterone system inhibitor use and COVID-19 hospitalization and death: a 1 4 million patient nationwide registry analysis ????Eur J Heart Fail http://www.kidney.de/pget.php?&tw=1&pmid=33222412 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33222412 #FOAvip English Wikipedia <ref>{{Cite pmid|33222412}}</ref> Association between renin-angiotensin-aldosterone system inhibitor use and COVID-19 hospitalization and death: a 1 4 million patient nationwide registry analysis #MMPMID33222412 Savarese G; Benson L; Sundstrom J; Lund LH Eur J Heart Fail 2021[Mar]; 23 (3): 476-485 PMID33222412show ga AIMS: Renin-angiotensin-aldosterone system inhibitors (RAASi) improve outcomes in cardiorenal disease but concerns have been raised over increased risk of incident hospitalization and death from coronavirus disease 2019 (COVID-19). We investigated the association between use of angiotensin-converting enzyme inhibitors (ACEi), angiotensin receptor blockers (ARBs) or mineralocorticoid receptor antagonists (MRAs) and COVID-19 hospitalization/death in a large nationwide population. METHODS AND RESULTS: Patients with hypertension, heart failure, diabetes, kidney disease, or ischaemic heart disease registered in the Swedish National Patient Registry until 1 February 2020 were included and followed until 31 May 2020. COVID-19 cases were defined based on hospitalization/death for COVID-19. Multivariable logistic and Cox regressions were fitted to investigate the association between ACEi/ARB and MRA and risk of hospitalization/death for COVID-19 in the overall population, and of all-cause mortality in COVID-19 cases. We performed consistency analysis to quantify the impact of potential unmeasured confounding. Of 1 387 746 patients (60% receiving ACEi/ARB and 5.8% MRA), 7146 (0.51%) had incident hospitalization/death from COVID-19. After adjustment for 45 variables, ACEi/ARB use was associated with a reduced risk of hospitalization/death for COVID-19 (odds ratio 0.86, 95% confidence interval 0.81-0.91) in the overall population, and with reduced mortality in COVID-19 cases (hazard ratio 0.89, 95% confidence interval 0.82-0.96). MRA use was not associated with risk of any outcome. Consistency analysis showed that unmeasured confounding would need to be large for there to be harmful signals associated with RAASi use. CONCLUSIONS: In a 1.4 million nationwide cohort, use of RAASi was not associated with increased risk of hospitalization for or death from COVID-19. |*COVID-19[MESH] |*Heart Failure/drug therapy/epidemiology[MESH] |*Hypertension[MESH] |Aldosterone[MESH] |Angiotensin Receptor Antagonists[MESH] |Angiotensin-Converting Enzyme Inhibitors/therapeutic use[MESH] |Hospitalization[MESH] |Humans[MESH] |Registries[MESH] |Renin-Angiotensin System[MESH] |Retrospective Studies[MESH]Association between renin-angiotensin-aldosterone system inhibitor use(epmc).pdf DeepDyve Pubget Overpricing