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10.1007/s00296-020-04749-4

http://scihub22266oqcxt.onion/10.1007/s00296-020-04749-4
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33219837!7680080!33219837
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suck abstract from ncbi


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pmid33219837      Rheumatol+Int 2021 ; 41 (1): 19-32
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  • Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management #MMPMID33219837
  • Kabeerdoss J; Pilania RK; Karkhele R; Kumar TS; Danda D; Singh S
  • Rheumatol Int 2021[Jan]; 41 (1): 19-32 PMID33219837show ga
  • Multisystem inflammatory syndrome (MIS-C) is a pediatric hyperinflammation disorder caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). It has now been reported from several countries the world over. Some of the clinical manifestations of MIS-C mimic Kawasaki disease (KD) shock syndrome. MIS-C develops 4-6 weeks following SARS-CoV-2 infection, and is presumably initiated by adaptive immune response. Though it has multisystem involvement, it is the cardiovascular manifestations that are most prominent. High titres of anti-SARS-CoV-2 antibodies are seen in these patients. As this is a new disease entity, its immunopathogenesis is not fully elucidated. Whether it has some overlap with KD is still unclear. Current treatment guidelines recommend use of intravenous immunoglobulin and high-dose corticosteroids as first-line treatment. Mortality rates of MIS-C are lower compared to adult forms of severe COVID-19 disease.
  • |COVID-19/diagnosis/*physiopathology/therapy[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Diagnosis, Differential[MESH]
  • |Humans[MESH]
  • |Immunoglobulins, Intravenous/administration & dosage[MESH]
  • |Mucocutaneous Lymph Node Syndrome/diagnosis/*physiopathology[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2[MESH]


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