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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Toxins+(Basel) 2020 ; 12 (11): ä Nephropedia Template TP
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Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia #MMPMID33218049
Vlaeminck J; Raafat D; Surmann K; Timbermont L; Normann N; Sellman B; van Wamel WJB; Malhotra-Kumar S
Toxins (Basel) 2020[Nov]; 12 (11): ä PMID33218049show ga
Pneumonia is an acute pulmonary infection associated with high mortality and an immense financial burden on healthcare systems. Staphylococcus aureus is an opportunistic pathogen capable of inducing S. aureus pneumonia (SAP), with some lineages also showing multidrug resistance. Given the high level of antibiotic resistance, much research has been focused on targeting S. aureus virulence factors, including toxins and biofilm-associated proteins, in an attempt to develop effective SAP therapeutics. Despite several promising leads, many hurdles still remain for S. aureus vaccine research. Here, we review the state-of-the-art SAP therapeutics, highlight their pitfalls, and discuss alternative approaches of potential significance and future perspectives.