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10.1038/s41577-020-00470-2 http://scihub22266oqcxt.onion/10.1038/s41577-020-00470-2 33214719!7675406!33214719     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2021 ; 21 (1): 49-64 Nephropedia Template TP {{tp|p=33214719|t=2021. Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 |pdf=|usr=}}{{33214719}} gab.com Text Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33214719 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Understanding of the fundamental processes underlying the versatile clinical manifestations of COVID-19 is incomplete without comprehension of how different immune cells are recruited to various compartments of virus-infected lungs, and how this recruitment differs among individuals with different levels of disease severity. As in other respiratory infections, leukocyte recruitment to the respiratory system in people with COVID-19 is orchestrated by specific leukocyte trafficking molecules, and when uncontrolled and excessive it results in various pathological complications, both in the lungs and in other organs. In the absence of experimental data from physiologically relevant animal models, our knowledge of the trafficking signals displayed by distinct vascular beds and epithelial cell layers in response to infection by SARS-CoV-2 is still incomplete. However, SARS-CoV-2 and influenza virus elicit partially conserved inflammatory responses in the different respiratory epithelial cells encountered early in infection and may trigger partially overlapping combinations of trafficking signals in nearby blood vessels. Here, we review the molecular signals orchestrating leukocyte trafficking to airway and lung compartments during primary pneumotropic influenza virus infections and discuss potential similarities to distinct courses of primary SARS-CoV-2 infections. We also discuss how an imbalance in vascular activation by leukocytes outside the airways and lungs may contribute to extrapulmonary inflammatory complications in subsets of patients with COVID-19. These multiple molecular pathways are potential targets for therapeutic interventions in patients with severe COVID-19. Twit Text FOAVip Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33214719 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33214719 #FOAvip English Wikipedia <ref>{{Cite pmid|33214719}}</ref> Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19 #MMPMID33214719 Alon R; Sportiello M; Kozlovski S; Kumar A; Reilly EC; Zarbock A; Garbi N; Topham DJ Nat Rev Immunol 2021[Jan]; 21 (1): 49-64 PMID33214719show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Understanding of the fundamental processes underlying the versatile clinical manifestations of COVID-19 is incomplete without comprehension of how different immune cells are recruited to various compartments of virus-infected lungs, and how this recruitment differs among individuals with different levels of disease severity. As in other respiratory infections, leukocyte recruitment to the respiratory system in people with COVID-19 is orchestrated by specific leukocyte trafficking molecules, and when uncontrolled and excessive it results in various pathological complications, both in the lungs and in other organs. In the absence of experimental data from physiologically relevant animal models, our knowledge of the trafficking signals displayed by distinct vascular beds and epithelial cell layers in response to infection by SARS-CoV-2 is still incomplete. However, SARS-CoV-2 and influenza virus elicit partially conserved inflammatory responses in the different respiratory epithelial cells encountered early in infection and may trigger partially overlapping combinations of trafficking signals in nearby blood vessels. Here, we review the molecular signals orchestrating leukocyte trafficking to airway and lung compartments during primary pneumotropic influenza virus infections and discuss potential similarities to distinct courses of primary SARS-CoV-2 infections. We also discuss how an imbalance in vascular activation by leukocytes outside the airways and lungs may contribute to extrapulmonary inflammatory complications in subsets of patients with COVID-19. These multiple molecular pathways are potential targets for therapeutic interventions in patients with severe COVID-19. |Animals[MESH] |COVID-19/epidemiology/*immunology/virology[MESH] |Cell Movement/*immunology[MESH] |Cytokines/immunology/metabolism[MESH] |Epidemics[MESH] |Humans[MESH] |Influenza, Human/*immunology/virology[MESH] |Leukocytes/*immunology/metabolism[MESH] |Lung/*immunology/metabolism/virology[MESH]Leukocyte trafficking to the lungs and beyond: lessons from influenza (epmc).pdf DeepDyve Pubget Overpricing