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10.1038/s41598-020-77093-z http://scihub22266oqcxt.onion/10.1038/s41598-020-77093-z 33214648!7677378!33214648     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 20191 Nephropedia Template TP {{tp|p=33214648|t=2020. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers |pdf=|usr=}}{{33214648}} gab.com Text Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33214648 #FOAvip COVID-19 is characterized by marked variability in clinical severity. Vitamin D had recently been reviewed as one of the factors that may affect the severity in COVID-19. The objective of current study is to analyze the vitamin D level in COVID-19 patients and its impact on the disease severity. After approval from Ethics Committee, M.L.B Medical College the current study was undertaken as continuous prospective observational study of 6 weeks. Participants were COVID-19 patients of age group 30-60 years admitted during the study period of 6 weeks. Study included either asymptomatic COVID-19 patients (Group A) or severely ill patients requiring ICU admission (Group B). Serum concentration of 25 (OH)D, were measured along with serum IL-6; TNFalpha and serum ferritin. Standard statistical analysis was performed to analyze the differences. Current Study enrolled 154 patients, 91 in Group A and 63 patients in Group B. The mean level of vitamin D (in ng/mL) was 27.89 +/- 6.21 in Group A and 14.35 +/- 5.79 in Group B, the difference was highly significant. The prevalence of vitamin D deficiency was 32.96% and 96.82% respectively in Group A and Group B. Out of total 154 patients, 90 patients were found to be deficient in vitamin D (Group A: 29; Group B: 61). Serum level of inflammatory markers was found to be higher in vitamin D deficient COVID-19 patients viz. IL-6 level (in pg/mL) 19.34 +/- 6.17 vs 12.18 +/- 4.29; Serum ferritin 319.17 +/- 38.21 ng/mL vs 186.83 +/- 20.18 ng/mL; TNFalpha level (in pg/mL) 13.26 +/- 5.64 vs 11.87 +/- 3.15. The fatality rate was high in vitamin D deficient (21% vs 3.1%). Vitamin D level is markedly low in severe COVID-19 patients. Inflammatory response is high in vitamin D deficient COVID-19 patients. This all translates into increased mortality in vitamin D deficient COVID-19 patients. As per the flexible approach in the current COVID-19 pandemic authors recommend mass administration of vitamin D supplements to population at risk for COVID-19. Twit Text FOAVip Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33214648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33214648 #FOAvip English Wikipedia <ref>{{Cite pmid|33214648}}</ref> Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers #MMPMID33214648 Jain A; Chaurasia R; Sengar NS; Singh M; Mahor S; Narain S Sci Rep 2020[Nov]; 10 (1): 20191 PMID33214648show ga COVID-19 is characterized by marked variability in clinical severity. Vitamin D had recently been reviewed as one of the factors that may affect the severity in COVID-19. The objective of current study is to analyze the vitamin D level in COVID-19 patients and its impact on the disease severity. After approval from Ethics Committee, M.L.B Medical College the current study was undertaken as continuous prospective observational study of 6 weeks. Participants were COVID-19 patients of age group 30-60 years admitted during the study period of 6 weeks. Study included either asymptomatic COVID-19 patients (Group A) or severely ill patients requiring ICU admission (Group B). Serum concentration of 25 (OH)D, were measured along with serum IL-6; TNFalpha and serum ferritin. Standard statistical analysis was performed to analyze the differences. Current Study enrolled 154 patients, 91 in Group A and 63 patients in Group B. The mean level of vitamin D (in ng/mL) was 27.89 +/- 6.21 in Group A and 14.35 +/- 5.79 in Group B, the difference was highly significant. The prevalence of vitamin D deficiency was 32.96% and 96.82% respectively in Group A and Group B. Out of total 154 patients, 90 patients were found to be deficient in vitamin D (Group A: 29; Group B: 61). Serum level of inflammatory markers was found to be higher in vitamin D deficient COVID-19 patients viz. IL-6 level (in pg/mL) 19.34 +/- 6.17 vs 12.18 +/- 4.29; Serum ferritin 319.17 +/- 38.21 ng/mL vs 186.83 +/- 20.18 ng/mL; TNFalpha level (in pg/mL) 13.26 +/- 5.64 vs 11.87 +/- 3.15. The fatality rate was high in vitamin D deficient (21% vs 3.1%). Vitamin D level is markedly low in severe COVID-19 patients. Inflammatory response is high in vitamin D deficient COVID-19 patients. This all translates into increased mortality in vitamin D deficient COVID-19 patients. As per the flexible approach in the current COVID-19 pandemic authors recommend mass administration of vitamin D supplements to population at risk for COVID-19. |Adult[MESH] |Asymptomatic Diseases/epidemiology[MESH] |Biomarkers/blood[MESH] |COVID-19/*blood/epidemiology/pathology[MESH] |Critical Illness/epidemiology[MESH] |Female[MESH] |Ferritins/blood[MESH] |Humans[MESH] |Interleukin-6/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Tumor Necrosis Factor-alpha/blood[MESH] |Vitamin D Deficiency/blood/*epidemiology[MESH]Analysis of vitamin D level among asymptomatic and critically ill COVI(epmc).pdf DeepDyve Pubget Overpricing