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10.1039/d0lc00678e http://scihub22266oqcxt.onion/10.1039/d0lc00678e 33211045!7855944!33211045     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Lab+Chip 2021 ; 21 (2): 331-343 Nephropedia Template TP {{tp|p=33211045|t=2021. A digital protein microarray for COVID-19 cytokine storm monitoring |pdf=|usr=}}{{33211045}} gab.com Text A digital protein microarray for COVID-19 cytokine storm monitoring JO: Lab Chip http://www.kidney.de/pget.php?&tw=1&pmid=33211045 #FOAvip Despite widespread concern regarding cytokine storms leading to severe morbidity in COVID-19, rapid cytokine assays are not routinely available for monitoring critically ill patients. We report the clinical application of a digital protein microarray platform for rapid multiplex quantification of cytokines from critically ill COVID-19 patients admitted to the intensive care unit (ICU) at the University of Michigan Hospital. The platform comprises two low-cost modules: (i) a semi-automated fluidic dispensing/mixing module that can be operated inside a biosafety cabinet to minimize the exposure of the technician to the virus infection and (ii) a 12-12-15 inch compact fluorescence optical scanner for the potential near-bedside readout. The platform enabled daily cytokine analysis in clinical practice with high sensitivity (<0.4 pg mL(-1)), inter-assay repeatability ( approximately 10% CV), and rapid operation providing feedback on the progress of therapy within 4 hours. This test allowed us to perform serial monitoring of two critically ill patients with respiratory failure and to support immunomodulatory therapy using the selective cytopheretic device (SCD). We also observed clear interleukin-6 (IL-6) elevations after receiving tocilizumab (IL-6 inhibitor) while significant cytokine profile variability exists across all critically ill COVID-19 patients and to discover a weak correlation between IL-6 to clinical biomarkers, such as ferritin and C-reactive protein (CRP). Our data revealed large subject-to-subject variability in patients' response to COVID-19, reaffirming the need for a personalized strategy guided by rapid cytokine assays. Twit Text FOAVip A digital protein microarray for COVID-19 cytokine storm monitoring ????Lab Chip http://www.kidney.de/pget.php?&tw=1&pmid=33211045 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33211045 #FOAvip English Wikipedia <ref>{{Cite pmid|33211045}}</ref> A digital protein microarray for COVID-19 cytokine storm monitoring #MMPMID33211045 Song Y; Ye Y; Su SH; Stephens A; Cai T; Chung MT; Han MK; Newstead MW; Yessayan L; Frame D; Humes HD; Singer BH; Kurabayashi K Lab Chip 2021[Jan]; 21 (2): 331-343 PMID33211045show ga Despite widespread concern regarding cytokine storms leading to severe morbidity in COVID-19, rapid cytokine assays are not routinely available for monitoring critically ill patients. We report the clinical application of a digital protein microarray platform for rapid multiplex quantification of cytokines from critically ill COVID-19 patients admitted to the intensive care unit (ICU) at the University of Michigan Hospital. The platform comprises two low-cost modules: (i) a semi-automated fluidic dispensing/mixing module that can be operated inside a biosafety cabinet to minimize the exposure of the technician to the virus infection and (ii) a 12-12-15 inch compact fluorescence optical scanner for the potential near-bedside readout. The platform enabled daily cytokine analysis in clinical practice with high sensitivity (<0.4 pg mL(-1)), inter-assay repeatability ( approximately 10% CV), and rapid operation providing feedback on the progress of therapy within 4 hours. This test allowed us to perform serial monitoring of two critically ill patients with respiratory failure and to support immunomodulatory therapy using the selective cytopheretic device (SCD). We also observed clear interleukin-6 (IL-6) elevations after receiving tocilizumab (IL-6 inhibitor) while significant cytokine profile variability exists across all critically ill COVID-19 patients and to discover a weak correlation between IL-6 to clinical biomarkers, such as ferritin and C-reactive protein (CRP). Our data revealed large subject-to-subject variability in patients' response to COVID-19, reaffirming the need for a personalized strategy guided by rapid cytokine assays. |Algorithms[MESH] |Biomarkers/blood[MESH] |C-Reactive Protein/analysis[MESH] |COVID-19/blood/*immunology[MESH] |Critical Illness[MESH] |Cytokine Release Syndrome/*blood/immunology[MESH] |Cytokines/*blood[MESH] |Digital Technology/*methods[MESH] |Enzyme-Linked Immunosorbent Assay/*methods[MESH] |Equipment Design[MESH] |Ferritins/analysis[MESH] |Interleukin-10/blood[MESH] |Interleukin-1beta/blood[MESH] |Interleukin-6/blood[MESH] |Limit of Detection[MESH] |Monitoring, Physiologic/instrumentation/*methods[MESH] |Protein Array Analysis/*methods[MESH] |SARS-CoV-2[MESH]A digital protein microarray for COVID-19 cytokine storm monitoring (epmc).pdf DeepDyve Pubget Overpricing