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10.1038/s41590-020-00832-x http://scihub22266oqcxt.onion/10.1038/s41590-020-00832-x 33208929!ä!33208929 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2021 ; 22 (1): 19-24 Nephropedia Template TP {{tp|p=33208929|t=2021. Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 |pdf=|usr=}}{{33208929}} gab.com Text Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33208929 #FOAvip Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation(1-3). The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)(4-7). RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19. Twit Text FOAVip Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33208929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33208929 #FOAvip English Wikipedia <ref>{{Cite pmid|33208929}}</ref> Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 #MMPMID33208929 Brunetta E; Folci M; Bottazzi B; De Santis M; Gritti G; Protti A; Mapelli SN; Bonovas S; Piovani D; Leone R; My I; Zanon V; Spata G; Bacci M; Supino D; Carnevale S; Sironi M; Davoudian S; Peano C; Landi F; Di Marco F; Raimondi F; Gianatti A; Angelini C; Rambaldi A; Garlanda C; Ciccarelli M; Cecconi M; Mantovani A Nat Immunol 2021[Jan]; 22 (1): 19-24 PMID33208929show ga Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation(1-3). The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)(4-7). RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19. |A549 Cells[MESH] |Adult[MESH] |C-Reactive Protein/*genetics/metabolism[MESH] |COVID-19/epidemiology/*genetics/virology[MESH] |Cell Line, Tumor[MESH] |Cells, Cultured[MESH] |Cohort Studies[MESH] |Endothelial Cells/metabolism[MESH] |Epidemics[MESH] |Female[MESH] |Gene Expression Profiling/*methods[MESH] |Humans[MESH] |Macrophages/*metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/metabolism[MESH] |Neutrophils/metabolism[MESH] |Prognosis[MESH] |SARS-CoV-2/*isolation & purification/physiology[MESH]Macrophage expression and prognostic significance of the long pentraxi(epmc).pdf DeepDyve Pubget Overpricing