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10.4049/jimmunol.2001067 http://scihub22266oqcxt.onion/10.4049/jimmunol.2001067 33208459!7750861!33208459     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2021 ; 206 (1): 37-50 Nephropedia Template TP {{tp|p=33208459|t=2021. Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile |pdf=|usr=}}{{33208459}} gab.com Text Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33208459 #FOAvip There is a pressing need for an in-depth understanding of immunity to SARS-CoV-2. In this study, we investigated human T cell recall responses to fully glycosylated spike trimer, recombinant N protein, as well as to S, N, M, and E peptide pools in the early convalescent phase and compared them with influenza-specific memory responses from the same donors. All subjects showed SARS-CoV-2-specific T cell responses to at least one Ag. Both SARS-CoV-2-specific and influenza-specific CD4(+) T cell responses were predominantly of the central memory phenotype; however SARS-CoV-2-specific CD4(+) T cells exhibited a lower IFN-gamma to TNF ratio compared with influenza-specific memory responses from the same donors, independent of disease severity. SARS-CoV-2-specific T cells were less multifunctional than influenza-specific T cells, particularly in severe cases, potentially suggesting exhaustion. Most SARS-CoV-2-convalescent subjects also produced IFN-gamma in response to seasonal OC43 S protein. We observed granzyme B(+)/IFN-gamma(+), CD4(+), and CD8(+) proliferative responses to peptide pools in most individuals, with CD4(+) T cell responses predominating over CD8(+) T cell responses. Peripheral T follicular helper (pTfh) responses to S or N strongly correlated with serum neutralization assays as well as receptor binding domain-specific IgA; however, the frequency of pTfh responses to SARS-CoV-2 was lower than the frequency of pTfh responses to influenza virus. Overall, T cell responses to SARS-CoV-2 are robust; however, CD4(+) Th1 responses predominate over CD8(+) T cell responses, have a more inflammatory profile, and have a weaker pTfh response than the response to influenza virus within the same donors, potentially contributing to COVID-19 disease. Twit Text FOAVip Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33208459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33208459 #FOAvip English Wikipedia <ref>{{Cite pmid|33208459}}</ref> Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile #MMPMID33208459 Law JC; Koh WH; Budylowski P; Lin J; Yue F; Abe KT; Rathod B; Girard M; Li Z; Rini JM; Mubareka S; McGeer A; Chan AK; Gingras AC; Watts TH; Ostrowski MA J Immunol 2021[Jan]; 206 (1): 37-50 PMID33208459show ga There is a pressing need for an in-depth understanding of immunity to SARS-CoV-2. In this study, we investigated human T cell recall responses to fully glycosylated spike trimer, recombinant N protein, as well as to S, N, M, and E peptide pools in the early convalescent phase and compared them with influenza-specific memory responses from the same donors. All subjects showed SARS-CoV-2-specific T cell responses to at least one Ag. Both SARS-CoV-2-specific and influenza-specific CD4(+) T cell responses were predominantly of the central memory phenotype; however SARS-CoV-2-specific CD4(+) T cells exhibited a lower IFN-gamma to TNF ratio compared with influenza-specific memory responses from the same donors, independent of disease severity. SARS-CoV-2-specific T cells were less multifunctional than influenza-specific T cells, particularly in severe cases, potentially suggesting exhaustion. Most SARS-CoV-2-convalescent subjects also produced IFN-gamma in response to seasonal OC43 S protein. We observed granzyme B(+)/IFN-gamma(+), CD4(+), and CD8(+) proliferative responses to peptide pools in most individuals, with CD4(+) T cell responses predominating over CD8(+) T cell responses. Peripheral T follicular helper (pTfh) responses to S or N strongly correlated with serum neutralization assays as well as receptor binding domain-specific IgA; however, the frequency of pTfh responses to SARS-CoV-2 was lower than the frequency of pTfh responses to influenza virus. Overall, T cell responses to SARS-CoV-2 are robust; however, CD4(+) Th1 responses predominate over CD8(+) T cell responses, have a more inflammatory profile, and have a weaker pTfh response than the response to influenza virus within the same donors, potentially contributing to COVID-19 disease. |Adult[MESH] |Aged[MESH] |Antigens, Viral/*immunology[MESH] |CD4-Positive T-Lymphocytes/*immunology[MESH] |Female[MESH] |Humans[MESH] |Inflammation/*immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Orthomyxoviridae/*immunology[MESH]Systematic Examination of Antigen-Specific Recall T Cell Responses to (epmc).pdf DeepDyve Pubget Overpricing