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10.3390/v12111313 http://scihub22266oqcxt.onion/10.3390/v12111313 33207802!7698105!33207802     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (11): ä Nephropedia Template TP {{tp|p=33207802|t=2020. Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera |pdf=|usr=}}{{33207802}} gab.com Text Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33207802 #FOAvip The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster. Coronaviruses are prone to host shifts, with recombination and positive selection possibly contributing to their high zoonotic potential. We analyzed the role of these two forces in the evolution of viruses belonging to the Betacoronavirus genus. The results showed that recombination has been pervasive during sarbecovirus evolution, and it is more widespread in this subgenus compared to the other two. In both sarbecoviruses and merbecoviruses, recombination hotspots are clearly observed. Conversely, positive selection was a less prominent force in sarbecoviruses compared to embecoviruses and merbecoviruses and targeted distinct genomic regions in the three subgenera, with S being the major target in sarbecoviruses alone. Overall, the results herein indicate that Betacoronavirus subgenera evolved along different trajectories, which might recapitulate their host preferences or reflect the origins of the presently available coronavirus sequences. Twit Text FOAVip Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33207802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33207802 #FOAvip English Wikipedia <ref>{{Cite pmid|33207802}}</ref> Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera #MMPMID33207802 Forni D; Cagliani R; Sironi M Viruses 2020[Nov]; 12 (11): ä PMID33207802show ga The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster. Coronaviruses are prone to host shifts, with recombination and positive selection possibly contributing to their high zoonotic potential. We analyzed the role of these two forces in the evolution of viruses belonging to the Betacoronavirus genus. The results showed that recombination has been pervasive during sarbecovirus evolution, and it is more widespread in this subgenus compared to the other two. In both sarbecoviruses and merbecoviruses, recombination hotspots are clearly observed. Conversely, positive selection was a less prominent force in sarbecoviruses compared to embecoviruses and merbecoviruses and targeted distinct genomic regions in the three subgenera, with S being the major target in sarbecoviruses alone. Overall, the results herein indicate that Betacoronavirus subgenera evolved along different trajectories, which might recapitulate their host preferences or reflect the origins of the presently available coronavirus sequences. |*Evolution, Molecular[MESH] |*Genetic Variation[MESH] |*Recombination, Genetic[MESH] |*Selection, Genetic[MESH] |Animals[MESH] |Betacoronavirus/*classification/*genetics[MESH] |Coronavirus Infections/virology[MESH] |Genome, Viral[MESH] |Genomics[MESH] |Host Microbial Interactions[MESH] |Humans[MESH] |Phylogeny[MESH]Recombination and Positive Selection Differentially Shaped the Diversi(epmc).pdf DeepDyve Pubget Overpricing