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10.3390/molecules25225346

http://scihub22266oqcxt.onion/10.3390/molecules25225346
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33207753!7696052!33207753
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suck abstract from ncbi


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pmid33207753      Molecules 2020 ; 25 (22): ä
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  • Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19 #MMPMID33207753
  • Bae M; Kim H
  • Molecules 2020[Nov]; 25 (22): ä PMID33207753show ga
  • Low levels of micronutrients have been associated with adverse clinical outcomes during viral infections. Therefore, to maximize the nutritional defense against infections, a daily allowance of vitamins and trace elements for malnourished patients at risk of or diagnosed with coronavirus disease 2019 (COVID-19) may be beneficial. Recent studies on COVID-19 patients have shown that vitamin D and selenium deficiencies are evident in patients with acute respiratory tract infections. Vitamin D improves the physical barrier against viruses and stimulates the production of antimicrobial peptides. It may prevent cytokine storms by decreasing the production of inflammatory cytokines. Selenium enhances the function of cytotoxic effector cells. Furthermore, selenium is important for maintaining T cell maturation and functions, as well as for T cell-dependent antibody production. Vitamin C is considered an antiviral agent as it increases immunity. Administration of vitamin C increased the survival rate of COVID-19 patients by attenuating excessive activation of the immune response. Vitamin C increases antiviral cytokines and free radical formation, decreasing viral yield. It also attenuates excessive inflammatory responses and hyperactivation of immune cells. In this mini-review, the roles of vitamin C, vitamin D, and selenium in the immune system are discussed in relation to COVID-19.
  • |*Dietary Supplements[MESH]
  • |Antibodies, Viral/biosynthesis[MESH]
  • |Ascorbic Acid/*therapeutic use[MESH]
  • |Betacoronavirus/drug effects/immunology/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diet therapy/immunology/*prevention & control/virology[MESH]
  • |Cytokine Release Syndrome/diet therapy/immunology/*prevention & control/virology[MESH]
  • |Cytokines/antagonists & inhibitors/biosynthesis[MESH]
  • |Host-Pathogen Interactions/drug effects/immunology[MESH]
  • |Humans[MESH]
  • |Immune System/drug effects[MESH]
  • |Immunologic Factors/therapeutic use[MESH]
  • |Micronutrients/therapeutic use[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/diet therapy/immunology/*prevention & control/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Selenium/*therapeutic use[MESH]
  • |T-Lymphocytes, Cytotoxic/drug effects/immunology/virology[MESH]


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