Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.cell.2020.10.052 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.10.052 33207184!7608014!33207184     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (6): 1508-1519.e12 Nephropedia Template TP {{tp|p=33207184|t=2020. Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality |pdf=|usr=}}{{33207184}} gab.com Text Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=33207184 #FOAvip The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress in the absence of well-defined correlates of immunity. While neutralization has been linked to protection against other pathogens, whether neutralization alone will be sufficient to drive protection against SARS-CoV-2 in the broader population remains unclear. Therefore, to fully define protective humoral immunity, we dissected the early evolution of the humoral response in 193 hospitalized individuals ranging from moderate to severe. Although robust IgM and IgA responses evolved in both survivors and non-survivors with severe disease, non-survivors showed attenuated IgG responses, accompanied by compromised Fc? receptor binding and Fc effector activity, pointing to deficient humoral development rather than disease-enhancing humoral immunity. In contrast, individuals with moderate disease exhibited delayed responses that ultimately matured. These data highlight distinct humoral trajectories associated with resolution of SARS-CoV-2 infection and the need for early functional humoral immunity. Twit Text FOAVip Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=33207184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33207184 #FOAvip English Wikipedia <ref>{{Cite pmid|33207184}}</ref> Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality #MMPMID33207184 Zohar T; Loos C; Fischinger S; Atyeo C; Wang C; Slein MD; Burke J; Yu J; Feldman J; Hauser BM; Caradonna T; Schmidt AG; Cai Y; Streeck H; Ryan ET; Barouch DH; Charles RC; Lauffenburger DA; Alter G Cell 2020[Dec]; 183 (6): 1508-1519.e12 PMID33207184show ga The urgent need for an effective SARS-CoV-2 vaccine has forced development to progress in the absence of well-defined correlates of immunity. While neutralization has been linked to protection against other pathogens, whether neutralization alone will be sufficient to drive protection against SARS-CoV-2 in the broader population remains unclear. Therefore, to fully define protective humoral immunity, we dissected the early evolution of the humoral response in 193 hospitalized individuals ranging from moderate to severe. Although robust IgM and IgA responses evolved in both survivors and non-survivors with severe disease, non-survivors showed attenuated IgG responses, accompanied by compromised Fc? receptor binding and Fc effector activity, pointing to deficient humoral development rather than disease-enhancing humoral immunity. In contrast, individuals with moderate disease exhibited delayed responses that ultimately matured. These data highlight distinct humoral trajectories associated with resolution of SARS-CoV-2 infection and the need for early functional humoral immunity. |*COVID-19/immunology/mortality[MESH] |*Immunity, Humoral[MESH] |Female[MESH] |HL-60 Cells[MESH] |Humans[MESH] |Immunoglobulin A/*immunology[MESH] |Immunoglobulin M/*immunology[MESH] |Male[MESH] |Receptors, IgG/*immunology[MESH]Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortal(epmc).pdf DeepDyve Pubget Overpricing