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10.7326/M20-6817

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33205991!7707213!33205991
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suck abstract from ncbi


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pmid33205991      Ann+Intern+Med 2021 ; 174 (3): 335-343
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  • Effectiveness of Adding a Mask Recommendation to Other Public Health Measures to Prevent SARS-CoV-2 Infection in Danish Mask Wearers : A Randomized Controlled Trial #MMPMID33205991
  • Bundgaard H; Bundgaard JS; Raaschou-Pedersen DET; von Buchwald C; Todsen T; Norsk JB; Pries-Heje MM; Vissing CR; Nielsen PB; Winslow UC; Fogh K; Hasselbalch R; Kristensen JH; Ringgaard A; Porsborg Andersen M; Goecke NB; Trebbien R; Skovgaard K; Benfield T; Ullum H; Torp-Pedersen C; Iversen K
  • Ann Intern Med 2021[Mar]; 174 (3): 335-343 PMID33205991show ga
  • BACKGROUND: Observational evidence suggests that mask wearing mitigates transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is uncertain if this observed association arises through protection of uninfected wearers (protective effect), via reduced transmission from infected mask wearers (source control), or both. OBJECTIVE: To assess whether recommending surgical mask use outside the home reduces wearers' risk for SARS-CoV-2 infection in a setting where masks were uncommon and not among recommended public health measures. DESIGN: Randomized controlled trial (DANMASK-19 [Danish Study to Assess Face Masks for the Protection Against COVID-19 Infection]). (ClinicalTrials.gov: NCT04337541). SETTING: Denmark, April and May 2020. PARTICIPANTS: Adults spending more than 3 hours per day outside the home without occupational mask use. INTERVENTION: Encouragement to follow social distancing measures for coronavirus disease 2019, plus either no mask recommendation or a recommendation to wear a mask when outside the home among other persons together with a supply of 50 surgical masks and instructions for proper use. MEASUREMENTS: The primary outcome was SARS-CoV-2 infection in the mask wearer at 1 month by antibody testing, polymerase chain reaction (PCR), or hospital diagnosis. The secondary outcome was PCR positivity for other respiratory viruses. RESULTS: A total of 3030 participants were randomly assigned to the recommendation to wear masks, and 2994 were assigned to control; 4862 completed the study. Infection with SARS-CoV-2 occurred in 42 participants recommended masks (1.8%) and 53 control participants (2.1%). The between-group difference was -0.3 percentage point (95% CI, -1.2 to 0.4 percentage point; P = 0.38) (odds ratio, 0.82 [CI, 0.54 to 1.23]; P = 0.33). Multiple imputation accounting for loss to follow-up yielded similar results. Although the difference observed was not statistically significant, the 95% CIs are compatible with a 46% reduction to a 23% increase in infection. LIMITATION: Inconclusive results, missing data, variable adherence, patient-reported findings on home tests, no blinding, and no assessment of whether masks could decrease disease transmission from mask wearers to others. CONCLUSION: The recommendation to wear surgical masks to supplement other public health measures did not reduce the SARS-CoV-2 infection rate among wearers by more than 50% in a community with modest infection rates, some degree of social distancing, and uncommon general mask use. The data were compatible with lesser degrees of self-protection. PRIMARY FUNDING SOURCE: The Salling Foundations.
  • |*Masks[MESH]
  • |Adult[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19 Serological Testing[MESH]
  • |COVID-19/diagnosis/*prevention & control/transmission[MESH]
  • |Denmark/epidemiology[MESH]
  • |Disease Transmission, Infectious/prevention & control[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Physical Distancing[MESH]


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