Natural history of COVID-19: back to basics #MMPMID33204429
Zayet S; Gendrin V; Klopfenstein T
New Microbes New Infect 2020[Nov]; 38 (ä): 100815 PMID33204429show ga
We retrospectively reconstituted the history of evolution and onset of the main symptoms of COVID-19 in 70 patients ([29 males, 41%] with a mean age of 56.7 +/- 19.3 [19-96] years). Firstly, pain syndrome defined by headache and/or myalgia and/or arthralgia (87%, n = 61) appeared as the first manifestation 1.6 day after the onset of the illness. Secondly, fever (76%, n = 53), followed by cough (80%, n = 56) and diarrhea (40%, n = 28). Thirty three patients (47.1%) were hospitalized on day 7 (+/-3) with a mean duration of hospitalization of 6.9 (+/-5.8 [1-21]) days. Twenty-three patients (32.9%) required oxygen therapy 6.7 (+/-4.1 [1-13]) days from illness onset. Fifteen patients had a respiratory rate >/=22/min on day 9 (+/-0.8) and only 8 patients (15%) were admitted or transferred in an ICU on day 10 (+/-2.7) with a mean duration of hospitalization in ICU of 7.9 (+/-6.6 [2-21]) days.