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10.1038/s42003-020-01408-z http://scihub22266oqcxt.onion/10.1038/s42003-020-01408-z 33203971!7673131!33203971     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Commun+Biol 2020 ; 3 (1): 682 Nephropedia Template TP {{tp|p=33203971|t=2020. Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function |pdf=|usr=}}{{33203971}} gab.com Text Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function JO: Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33203971 #FOAvip Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy samples of human hearts, and a mouse model of "binge and crash" methamphetamine administration. Sigmar1 expression is significantly decreased in the hearts of human methamphetamine users and those of "binge and crash" methamphetamine-treated mice. The hearts of methamphetamine users also show signs of cardiomyopathy, including cellular injury, fibrosis, and enlargement of the heart. In addition, mice expose to "binge and crash" methamphetamine develop cardiac hypertrophy, fibrotic remodeling, and mitochondrial dysfunction leading to contractile dysfunction. Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function. Therefore, Sigmar1 is a viable therapeutic agent for protection against methamphetamine-associated cardiomyopathy. Twit Text FOAVip Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function ????Commun Biol http://www.kidney.de/pget.php?&tw=1&pmid=33203971 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33203971 #FOAvip English Wikipedia <ref>{{Cite pmid|33203971}}</ref> Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function #MMPMID33203971 Abdullah CS; Aishwarya R; Alam S; Morshed M; Remex NS; Nitu S; Kolluru GK; Traylor J; Miriyala S; Panchatcharam M; Hartman B; King J; Bhuiyan MAN; Chandran S; Woolard MD; Yu X; Goeders NE; Dominic P; Arnold CL; Stokes K; Kevil CG; Orr AW; Bhuiyan MS Commun Biol 2020[Nov]; 3 (1): 682 PMID33203971show ga Methamphetamine-associated cardiomyopathy is the leading cause of death linked with illicit drug use. Here we show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy and defined the molecular mechanisms using autopsy samples of human hearts, and a mouse model of "binge and crash" methamphetamine administration. Sigmar1 expression is significantly decreased in the hearts of human methamphetamine users and those of "binge and crash" methamphetamine-treated mice. The hearts of methamphetamine users also show signs of cardiomyopathy, including cellular injury, fibrosis, and enlargement of the heart. In addition, mice expose to "binge and crash" methamphetamine develop cardiac hypertrophy, fibrotic remodeling, and mitochondrial dysfunction leading to contractile dysfunction. Methamphetamine treatment inhibits Sigmar1, resulting in inactivation of the cAMP response element-binding protein (CREB), decreased expression of mitochondrial fission 1 protein (FIS1), and ultimately alteration of mitochondrial dynamics and function. Therefore, Sigmar1 is a viable therapeutic agent for protection against methamphetamine-associated cardiomyopathy. |Animals[MESH] |Cardiomyopathies/*chemically induced/prevention & control[MESH] |Cyclic AMP Response Element-Binding Protein/genetics/metabolism[MESH] |Drug Administration Schedule[MESH] |Gene Expression Regulation/drug effects[MESH] |Heart/drug effects[MESH] |Humans[MESH] |Methamphetamine/administration & dosage/*toxicity[MESH] |Mice[MESH] |Mitochondria/*drug effects/metabolism[MESH] |Mitochondrial Proteins/genetics/metabolism[MESH] |Myocardium/pathology[MESH] |Myocytes, Cardiac/drug effects[MESH] |Receptors, sigma/genetics/*metabolism[MESH]Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent(epmc).pdf DeepDyve Pubget Overpricing