Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/s41467-020-19684-y http://scihub22266oqcxt.onion/10.1038/s41467-020-19684-y 33203860!7672082!33203860     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2020 ; 11 (1): 5838 Nephropedia Template TP {{tp|p=33203860|t=2020. STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters |pdf=|usr=}}{{33203860}} gab.com Text STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33203860 #FOAvip Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneumonia and strong inflammatory responses in the lungs with neutrophil infiltration and edema, further confirmed as consolidations visualized by micro-CT alike in clinical practice. Moreover, we identify an exuberant innate immune response as key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients. Twit Text FOAVip STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33203860 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33203860 #FOAvip English Wikipedia <ref>{{Cite pmid|33203860}}</ref> STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters #MMPMID33203860 Boudewijns R; Thibaut HJ; Kaptein SJF; Li R; Vergote V; Seldeslachts L; Van Weyenbergh J; De Keyzer C; Bervoets L; Sharma S; Liesenborghs L; Ma J; Jansen S; Van Looveren D; Vercruysse T; Wang X; Jochmans D; Martens E; Roose K; De Vlieger D; Schepens B; Van Buyten T; Jacobs S; Liu Y; Marti-Carreras J; Vanmechelen B; Wawina-Bokalanga T; Delang L; Rocha-Pereira J; Coelmont L; Chiu W; Leyssen P; Heylen E; Schols D; Wang L; Close L; Matthijnssens J; Van Ranst M; Compernolle V; Schramm G; Van Laere K; Saelens X; Callewaert N; Opdenakker G; Maes P; Weynand B; Cawthorne C; Vande Velde G; Wang Z; Neyts J; Dallmeier K Nat Commun 2020[Nov]; 11 (1): 5838 PMID33203860show ga Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search for key targets of effective therapeutics, robust animal models mimicking COVID-19 in humans are urgently needed. Here, we show that Syrian hamsters, in contrast to mice, are highly permissive to SARS-CoV-2 and develop bronchopneumonia and strong inflammatory responses in the lungs with neutrophil infiltration and edema, further confirmed as consolidations visualized by micro-CT alike in clinical practice. Moreover, we identify an exuberant innate immune response as key player in pathogenesis, in which STAT2 signaling plays a dual role, driving severe lung injury on the one hand, yet restricting systemic virus dissemination on the other. Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients. |*Disease Models, Animal[MESH] |*Signal Transduction[MESH] |Animals[MESH] |Betacoronavirus/pathogenicity/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/metabolism/*pathology/*virology[MESH] |Cricetinae[MESH] |Immunity, Innate[MESH] |Interferon Type I/genetics/metabolism[MESH] |Lung/pathology/virology[MESH] |Mice[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/metabolism/*pathology/*virology[MESH] |SARS-CoV-2[MESH] |STAT2 Transcription Factor/genetics/*metabolism[MESH]STAT2 signaling restricts viral dissemination but drives severe pneumo(epmc).pdf DeepDyve Pubget Overpricing