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10.1016/j.ijid.2020.11.145

http://scihub22266oqcxt.onion/10.1016/j.ijid.2020.11.145
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33202218!7666570!33202218
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suck abstract from ncbi


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pmid33202218      Int+J+Infect+Dis 2021 ; 102 (ä): 319-326
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  • Characteristics of pediatric multi-system inflammatory syndrome (PMIS) associated with COVID-19: a meta-analysis and insights into pathogenesis #MMPMID33202218
  • Zou H; Lu J; Liu J; Wong JH; Cheng S; Li Q; Shen Y; Li C; Jia X
  • Int J Infect Dis 2021[Jan]; 102 (ä): 319-326 PMID33202218show ga
  • OBJECTIVES: There was an outbreak of pediatric multisystem inflammation syndrome (PMIS) was observed in multiple countries recently, and this syndrome was suspected to be associated with SARS-CoV-2 infection. At present, there is still no standardized diagnostic criteria and treatment regimen for PMIS, while the etiology and pathogenesis still remain unclear. METHODS: We performed a systematic review on PubMed and Embase from the time of inception to June 24th 2020 in order to find relevant cases. RESULTS: There are seven studies included, and 80% of patients suffered persistent fever and 90% appeared gastrointestinal symptoms. IgG antibody against SARS-CoV-2 was positive on 81% of patients, while 37% of the patients were nucleic acid positive. C-reactive protein, IL-6 and PCT were elevated and intravenous immunoglobulin was a routine treatment for PMIS. There were more than half of patients required inotropic supports and mechanical ventilation were applied to 33% of patients. The median length of hospital stay was 10.66 days and 74% had admitted to accept intensive care. CONCLUSIONS: Our study documented three common types of PMIS clinical presentation: persistent fever and gastrointestinal symptoms, shocked with heart dysfunction and Kawasaki disease-like syndrome. PMIS patients proved with a marked inflammatory state were possibly associated with SARS-CoV-2 infection.
  • |*COVID-19 Drug Treatment[MESH]
  • |Adolescent[MESH]
  • |COVID-19/*diagnosis/virology[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Critical Care[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunoglobulin G/administration & dosage[MESH]
  • |Length of Stay[MESH]
  • |Male[MESH]
  • |Respiration, Artificial[MESH]
  • |SARS-CoV-2/physiology[MESH]


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