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10.1134/S0006297920100077

http://scihub22266oqcxt.onion/10.1134/S0006297920100077
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33202204!7590567!33202204
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suck abstract from ncbi

pmid33202204      Biochemistry+(Mosc) 2020 ; 85 (10): 1191-1201
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  • Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors #MMPMID33202204
  • Zamaraev AV; Zhivotovsky B; Kopeina GS
  • Biochemistry (Mosc) 2020[Oct]; 85 (10): 1191-1201 PMID33202204show ga
  • The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proapoptotic proteins and signaling pathways, which facilitates carcinogenesis. Ineffective immune surveillance or immune response suppression can induce uncontrolled virus propagation and host cell proliferation. In this review, we discuss current data that provide insights into mechanisms of apoptotic death suppression by viruses and their role in oncogenesis.
  • |*Apoptosis[MESH]
  • |*Carcinogenesis[MESH]
  • |Cell Line, Tumor[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Mitochondria/metabolism[MESH]
  • |NF-kappa B/metabolism[MESH]
  • |Oncogenic Viruses/*physiology[MESH]
  • |Phosphatidylinositol 3-Kinases/metabolism[MESH]
  • |Tumor Suppressor Protein p53/metabolism[MESH]


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