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10.1098/rsob.200237 http://scihub22266oqcxt.onion/10.1098/rsob.200237 33202171!7729036!33202171     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Open+Biol 2020 ; 10 (11): 200237 Nephropedia Template TP {{tp|p=33202171|t=2020. Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential |pdf=|usr=}}{{33202171}} gab.com Text Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential JO: Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=33202171 #FOAvip Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation. This brought them into focus as promising therapeutic targets, albeit the close homology to some of the human macrodomains raised concerns regarding potential cross-reactivity and adverse effects for the host. Here, we evaluate the structure and function of the macrodomain of SARS-CoV-2, the causative agent of COVID-19. We show that it can antagonize ADP-ribosylation by PARP14, a cellular (ADP-ribosyl)transferase necessary for the restriction of coronaviral infections. Furthermore, our structural studies together with ligand modelling revealed the structural basis for poly(ADP-ribose) binding and hydrolysis, an emerging new aspect of viral macrodomain biology. These new insights were used in an extensive evolutionary analysis aimed at evaluating the druggability of viral macrodomains not only from the Coronaviridae but also Togaviridae and Iridoviridae genera (causing diseases such as Chikungunya and infectious spleen and kidney necrosis virus disease, respectively). We found that they contain conserved features, distinct from their human counterparts, which may be exploited during drug design. Twit Text FOAVip Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential ????Open Biol http://www.kidney.de/pget.php?&tw=1&pmid=33202171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33202171 #FOAvip English Wikipedia <ref>{{Cite pmid|33202171}}</ref> Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential #MMPMID33202171 Rack JGM; Zorzini V; Zhu Z; Schuller M; Ahel D; Ahel I Open Biol 2020[Nov]; 10 (11): 200237 PMID33202171show ga Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation. This brought them into focus as promising therapeutic targets, albeit the close homology to some of the human macrodomains raised concerns regarding potential cross-reactivity and adverse effects for the host. Here, we evaluate the structure and function of the macrodomain of SARS-CoV-2, the causative agent of COVID-19. We show that it can antagonize ADP-ribosylation by PARP14, a cellular (ADP-ribosyl)transferase necessary for the restriction of coronaviral infections. Furthermore, our structural studies together with ligand modelling revealed the structural basis for poly(ADP-ribose) binding and hydrolysis, an emerging new aspect of viral macrodomain biology. These new insights were used in an extensive evolutionary analysis aimed at evaluating the druggability of viral macrodomains not only from the Coronaviridae but also Togaviridae and Iridoviridae genera (causing diseases such as Chikungunya and infectious spleen and kidney necrosis virus disease, respectively). We found that they contain conserved features, distinct from their human counterparts, which may be exploited during drug design. |*ADP-Ribosylation[MESH] |*Molecular Docking Simulation[MESH] |Adenosine Diphosphate Ribose/chemistry/metabolism[MESH] |Binding Sites[MESH] |Evolution, Molecular[MESH] |Humans[MESH] |Poly(ADP-ribose) Polymerases/*chemistry/genetics/metabolism[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |RNA-Dependent RNA Polymerase/*chemistry/genetics/metabolism[MESH] |Recombinant Proteins/chemistry/genetics/metabolism[MESH]Viral macrodomains: a structural and evolutionary assessment of the p(epmc).pdf DeepDyve Pubget Overpricing