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10.1038/s41598-020-76836-2 http://scihub22266oqcxt.onion/10.1038/s41598-020-76836-2 33199778!7670444!33199778     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2020 ; 10 (1): 19839 Nephropedia Template TP {{tp|p=33199778|t=2020. Similarities and differences between the cytokine storms in acute dengue and COVID-19 |pdf=|usr=}}{{33199778}} gab.com Text Similarities and differences between the cytokine storms in acute dengue and COVID-19 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33199778 #FOAvip Severe pneumonia and multiorgan dysfunction in COVID-19 and dengue haemorrhagic fever (DHF) are two diseases that can associate with an altered immune response to the infecting virus. To determine the similarities and differences in the cytokine and chemokine responses in these two infections, we compared responses in patients with varying severity of COVID-19 and acute dengue at different time points of illness. During early disease, patients who proceeded to develop COVID-19 severe pneumonia (SP) and DHF had significantly higher levels of IL-6, IL-10 and MIP3alpha than those who developed mild illness. The lowest levels of IFNgamma in early illness were seen in those who succumbed to their illness due to COVID-19. Levels of serum IL-10 (p = 0.0001), IL-6 (p = 0.002), MIP-3alpha (p = 0.02) and CD40-L levels (p = 0.002) significantly increased from 5 to 9 day of illness to 10-21 day of illness in patients with moderate-to-severe COVID-19, but not in those with mild illness. In contrast, these cytokine/chemokine levels remained unchanged in those with DHF or dengue fever (DF) during febrile and critical phases. Although IL-10 levels were significantly higher in COVID-19 patients with SP, patients with DHF had 25-fold higher levels, whereas IL-6 levels were 11-fold higher in those with COVID-19 SP. IL-10 and other cytokines were evaluated in a larger cohort of patients during early illness (</= 4 days) who proceeded to develop DF (n = 71) or DHF (n = 64). Of the cytokines evaluated, IL-10 was significantly higher (p < 0.0001) in those who went on to develop DHF compared to DF. Low IFNgamma response to the SARS-CoV2 and high levels of immunosuppressive IL-10 in both COVID-19 and dengue during early illness are indicators of an altered antiviral response potentially contributing to disease severity. Twit Text FOAVip Similarities and differences between the cytokine storms in acute dengue and COVID-19 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33199778 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33199778 #FOAvip English Wikipedia <ref>{{Cite pmid|33199778}}</ref> Similarities and differences between the cytokine storms in acute dengue and COVID-19 #MMPMID33199778 Dayarathna S; Jeewandara C; Gomes L; Somathilaka G; Jayathilaka D; Vimalachandran V; Wijewickrama A; Narangoda E; Idampitiya D; Ogg GS; Malavige GN Sci Rep 2020[Nov]; 10 (1): 19839 PMID33199778show ga Severe pneumonia and multiorgan dysfunction in COVID-19 and dengue haemorrhagic fever (DHF) are two diseases that can associate with an altered immune response to the infecting virus. To determine the similarities and differences in the cytokine and chemokine responses in these two infections, we compared responses in patients with varying severity of COVID-19 and acute dengue at different time points of illness. During early disease, patients who proceeded to develop COVID-19 severe pneumonia (SP) and DHF had significantly higher levels of IL-6, IL-10 and MIP3alpha than those who developed mild illness. The lowest levels of IFNgamma in early illness were seen in those who succumbed to their illness due to COVID-19. Levels of serum IL-10 (p = 0.0001), IL-6 (p = 0.002), MIP-3alpha (p = 0.02) and CD40-L levels (p = 0.002) significantly increased from 5 to 9 day of illness to 10-21 day of illness in patients with moderate-to-severe COVID-19, but not in those with mild illness. In contrast, these cytokine/chemokine levels remained unchanged in those with DHF or dengue fever (DF) during febrile and critical phases. Although IL-10 levels were significantly higher in COVID-19 patients with SP, patients with DHF had 25-fold higher levels, whereas IL-6 levels were 11-fold higher in those with COVID-19 SP. IL-10 and other cytokines were evaluated in a larger cohort of patients during early illness ( |COVID-19/*blood/immunology/pathology[MESH] |Chemokine CCL20/blood[MESH] |Cytokine Release Syndrome/*blood/immunology/pathology[MESH] |Dengue/*blood/immunology/pathology[MESH] |Humans[MESH] |Interferon-gamma/blood[MESH] |Interleukin-10/blood[MESH]Similarities and differences between the cytokine storms in acute de(epmc).pdf DeepDyve Pubget Overpricing