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10.1038/s41598-020-76914-5

http://scihub22266oqcxt.onion/10.1038/s41598-020-76914-5
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33199713!7669901!33199713
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suck abstract from ncbi


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pmid33199713      Sci+Rep 2020 ; 10 (1): 19893
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  • Detection of SARS-CoV-2 antibodies is insufficient for the diagnosis of active or cured COVID-19 #MMPMID33199713
  • Escribano P; Alvarez-Uria A; Alonso R; Catalan P; Alcala L; Munoz P; Guinea J
  • Sci Rep 2020[Nov]; 10 (1): 19893 PMID33199713show ga
  • We assessed the performance of Abbott's SARS-CoV-2 IgG assay and the Panbio(TM) COVID-19 IgG/IgM rapid test device for the diagnosis of either active or cured COVID-19. Three cohorts of patients were chosen. Cohort 1, patients (n = 65) who attended the emergency department on March 30, 2020 with clinical suspicion of active COVID-19 (n = 56 with proven/probable COVID-19). Cohort 2, hospital workers (n = 92) who had either been (n = 40) or not (n = 52) diagnosed with proven/probable COVID-19 and were asymptomatic at the time of the sampling. Cohort 3, patients (n = 38) cared at the hospital before the start of the COVID-19 pandemic. Detection of serum antibodies was done using Abbott s SARS-CoV-2 IgG assay and the Panbio(TM) COVID-19 IgG/IgM device. Both methods showed 98% agreement for IgG detection. No antibodies were detected in the 38 samples from hospitalized pre-COVID subjects. The diagnostic performance of IgGs detected by Abbott s SARS-CoV-2 assay in Cohorts 1/2 was: sensitivity (60.7%/75%) and specificity (100%/84.6%). The diagnostic performance of IgM by Panbio(TM) COVID-19 in Cohorts 1/2 was: sensitivity (16%/17.5%) and specificity (100%/98.1%). We show that IgG detection alone is insufficient for the diagnosis of active or cured COVID-19. IgM detection has a limited diagnostic value.
  • |Aged[MESH]
  • |COVID-19 Serological Testing/*standards[MESH]
  • |COVID-19/blood/*diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Reagent Kits, Diagnostic/*standards[MESH]


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