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10.1016/j.cytogfr.2020.10.005

http://scihub22266oqcxt.onion/10.1016/j.cytogfr.2020.10.005
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33199178!7583616!33199178
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suck abstract from ncbi


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pmid33199178      Cytokine+Growth+Factor+Rev 2021 ; 58 (ä): 49-50
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  • A clinical trial of IL-15 and IL-21 combination therapy for COVID-19 is warranted #MMPMID33199178
  • Wilz SW
  • Cytokine Growth Factor Rev 2021[Apr]; 58 (ä): 49-50 PMID33199178show ga
  • Previous studies of SARS-CoV-2 viral infection suggest that both the humoral and cytotoxic arms of the immune system are weak in patients with severe COVID-19 disease when compared to mild disease. A cytokine storm is also induced in severe disease. IL-15 has been shown to support the cytotoxic arm of the immune response. IL-21 has been shown to support both the cytotoxic and humoral arms of the immune response. In addition, in some settings, Il-21 has been shown to actually decrease IL-6 and TNF-alpha production, reducing the inflammatory proteins involved in the cytokine storm. Furthermore, in other settings, the combination of IL-15 and IL-21 has been shown to be more effective than either interleukin alone in promoting an effective immune response. Therefore, a clinical trial that examines the use of the combination of IL-15 and IL-21 for COVID-19 patients is warranted.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Clinical Trials as Topic[MESH]
  • |COVID-19/complications/immunology[MESH]
  • |Cytokine Release Syndrome/etiology/prevention & control[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Humans[MESH]
  • |Interleukin-15/*administration & dosage[MESH]
  • |Interleukins/*administration & dosage[MESH]
  • |Research Design[MESH]


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