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10.1016/j.bbrep.2020.100838 http://scihub22266oqcxt.onion/10.1016/j.bbrep.2020.100838 33195828!7642770!33195828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33195828&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Biochem+Biophys+Rep 2020 ; 24 (?): 100838 Nephropedia Template TP {{tp|p=33195828|t=2020. Binding of the small-molecule kinase inhibitor ruxolitinib to membranes does not disturb membrane integrity |pdf=|usr=}}{{33195828}} gab.com Text Binding of the small-molecule kinase inhibitor ruxolitinib to membranes does not disturb membrane integrity JO: Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=33195828 #FOAvip Ruxolitinib is a small-molecule protein kinase inhibitor, which is used as a therapeutic agent against several diseases. Due to its anti-inflammatory impact, ruxolitinib has also been considered recently for usage in the treatment of Covid-19. While the specific effects of ruxolitinib on Janus kinases (JAK) is comparatively well investigated, its (unspecific) impact on membranes has not been studied in detail so far. Therefore, we characterized the interaction of this drug with lipid membranes employing different biophysical approaches. Ruxolitinib incorporates into the glycerol region of lipid membranes causing an increase in disorder of the lipid chains. This binding, however, has only marginal influence on the structure and integrity of membranes as found by leakage and permeation assays. Twit Text FOAVip Binding of the small-molecule kinase inhibitor ruxolitinib to membranes does not disturb membrane integrity ????Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=33195828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33195828 #FOAvip English Wikipedia <ref>{{Cite pmid|33195828}}</ref> Binding of the small-molecule kinase inhibitor ruxolitinib to membranes does not disturb membrane integrity #MMPMID33195828 Fischer M; Luck M; Werle M; Scheidt HA; Muller P Biochem Biophys Rep 2020[Dec]; 24 (?): 100838 PMID33195828show ga Ruxolitinib is a small-molecule protein kinase inhibitor, which is used as a therapeutic agent against several diseases. Due to its anti-inflammatory impact, ruxolitinib has also been considered recently for usage in the treatment of Covid-19. While the specific effects of ruxolitinib on Janus kinases (JAK) is comparatively well investigated, its (unspecific) impact on membranes has not been studied in detail so far. Therefore, we characterized the interaction of this drug with lipid membranes employing different biophysical approaches. Ruxolitinib incorporates into the glycerol region of lipid membranes causing an increase in disorder of the lipid chains. This binding, however, has only marginal influence on the structure and integrity of membranes as found by leakage and permeation assays. ?Binding of the small-molecule kinase inhibitor ruxolitinib to membrane(epmc).pdf DeepDyve Pubget Overpricing